| Project/Area Number |
61480338
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | AKITA UNIVERSITY |
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Principal Investigator |
TSUCHIDA Seigi Akita University, Professor, 医学部, 教授 (00004549)
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| Co-Investigator(Kenkyū-buntansha) |
NOTO Hiromitsu Akita University, Assistant Professor, 医学部, 助手 (60164711)
MIYAGATA Shigeru Akita University, Assistant Professor, 医学部, 助手 (00157596)
NISHIZAWA Osamu Akita University, Assistant Professor, 医学部, 講師 (60091815)
HARADA Tadashi Akita University, Assistant Professor, 医学部, 講師 (00108953)
ARAI Shigeru Yamagata University, Professor, 医学部, 教授 (90004580)
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| Project Period (FY) |
1986 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥6,600,000 (Direct Cost: ¥6,600,000)
Fiscal Year 1988: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1987: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1986: ¥4,100,000 (Direct Cost: ¥4,100,000)
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| Keywords | Vesicoureteric reflux / VUR / Mechanism of VUR Prevention / 逆流防止手術 / 腎組織 / 尿管蠕動 |
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| Research Abstract |
Present study shows that vesicoureteric reflux was prevented by closing of intramucosal ureteral lumen. Ultrasound examination revealed that intramucosal ureteral lumen was closed except urine expulsion from ureteral orifice by peristalsis. Incomplete closing of intramucosal ureteral lumen was occurred by deficit of mucosal and/or muscle layers.
VUR was classified into two groups-reversible VUR and irreversible VUR-according to responsibility to treatment. The reversible VUR was cured spontaneously or by conservative treatment. The irreversible VUR which did not respond to medical treatment was due to inflammatory sclerotic changes of mucosal and muscle layers.
In sixteen cases results of the anti-reflux operation were evaluated. The degree and existence of VUR renal function, degree of urinary tract dilatation, proteinuria and urinary tract inefection were observed on each case before and after operation. Fourteen out of 16 cases were estimated to be successful, on the other hand 2 cases were estimated to be unsuccessful. The one unsuccessful case received hemodialysis due to progressive deteriorated renal function, and another case developed recurrence of VUR.
In two cases urine flow around ureteral orifice was evaluated by color doppler technique before and after anti-reflux operation. Downward flow was detected, but upward flow was not detected. The evaluation of urine flow around ureteral orifice by color doppler technique might be useful method for the detection of VUR.
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