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Study on development and regression of choroidal neovascularization

Research Project

Project/Area Number 61480371
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionKansai Medical Unviersity

Principal Investigator

TSUKAHARA Isamu  Kansai Medical University, 学長 (90077579)

Co-Investigator(Kenkyū-buntansha) KATOH Naoko  Department of Ophthalmology, Kansai Medical University, 医学部(眼科学), 助手 (10194838)
YAMAGISHI Kazuya  Department of Ophthalmology, Kansai Medical University, 医学部(眼科学), 助手 (90174599)
ITAGAKI Takashi  Department of Ophthalmology, Kansai Medical University, 医学部(眼科学), 講師 (30140255)
OHKUMA Hiroshi  Department of Ophthalmology, Kansai Medical University, 医学部(眼科学), 講師 (70077775)
UYAMA Masanobu  Department of Ophthalmology, Kansai Medical University, 医学部(眼科学), 教授 (30025580)
西村 哲哉  関西医科大学, 医学部(眼科学), 講師 (30156111)
Project Period (FY) 1986 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥6,800,000 (Direct Cost: ¥6,800,000)
Fiscal Year 1987: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1986: ¥4,800,000 (Direct Cost: ¥4,800,000)
KeywordsChoroidal neovascularzation / Subretinal neovascularization / Retinal pigment epithelium / Neovascular maculopathy / Senile disciform macular degeneration / Laser photocoagulation / Ornithine / ヨード酸ソーダ
Research Abstract

Senile disciform macular degeneration is increasing as a cause of blindness of elderly aged people. To clarify pathogenasis and rationale of treatment of the degeneration, experimental work on choroidal neovascularization (ChNV) was done.
ChNVs were produced experimentally in the posterior pole of monkey eyes, by means of krypton laser photocoagulation (LP). In our previous studies on natural course of experimentally produced BhNV, we showed that in course of development of ChNV, ChNVs were slways accompanied with the retinal pigment epithelium(RPE) cells in the subretinal space, and in spontaneous regression, ChNVs were always sealed by a layer of proliferated RPE cells beneath the sensory retina. These results suggested RPE contribute greatly to development and regression of ChNV.
To confirm our thoughts, we have used drugs, which damage RPE selectively. A small smount of ornithine hydrochloride solution was injected into the intravitreous cavity before or after LP. Intravitreal administration of ornithine produced severe damage on RPE selectively. In pretreatment of ornithine (2 weeks before LP), ChNV did not occurred at all, following PC. Budding, However, of some newly formed vessels from the choroidal vessels were observed beneath Bruch's membrane following PC, but they did not grow towards the subretinal space through Bruch's membrane. And proliferation of RPE was not seen following PC.
In posttreatment of ornithine (2 weeks after LP), when ChNV has already developed in the subretinal space, ChNV, has persisted over 10 weeks without spontaneous regression. Sealing by RPE was not seen.
These results showed that in course of development of ChNV, accompany of proliferated and migrated RPE cells to ChNV was necessary, and regression of ChNV was manifested by sealing of a layer of RPE and RPE has a close relation to process of ChNV.

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] Masanobu Uyama: Documenta Ophthalmologica Proceedings Series Ocular Circulation and Neo vascalarization. 50. 451-459 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 加藤直子, 大熊紘, 板垣隆, 山岸和矢, 宇山昌延: 日本眼科学会雑誌. 90. 283-290 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 加藤直子, 大熊紘, 板垣隆, 山岸和矢, 宇山昌延: 日本眼科学会雑誌. 90. 898-907 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 板垣隆, 大熊紘, 宇山昌延: 臨床眼科. 40. 213-216 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 三木耕一郎, Stephen J. Ryan, 大熊紘, 宇山昌延: 日本眼科学会雑誌. 90. 749-756 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 山岸和矢, 大熊紘, 板垣隆, 加藤直子, 宇山昌延: 日本眼科紀要. 37. 1154-1157 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 板垣隆, 大熊紘, 山岸和矢, 加藤直子, 宇山昌延: 日本眼科学会雑誌. 90. 1217-1225 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 板垣隆, 大熊紘, 山岸和矢, 高橋寛二, 宇山昌延: セラビューティック・リサーチ. 5. 665-670 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Masanobu Uyama, Hiroshi Ohkuma, Takashi Itagaki, Kazuya Yamagishi, Tesuya Nishimura, Kanji Takahashi: "Choroidal Neovascularization And The Retinal Pigment Epithelium" Documenta Ophthalmologica Proceedings Series Ocular Circulaion and Neovascularization. 50. 451-459 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Naoko Katoh, Hiroshi Ohkuma, Takashi Itagaki, Kazuya Yamagishi, Masanobu Uyama: "A Comparative study of Effects of Photocoagulation with the Argon Blue-Green and Krypton Red Lasers on the Retina and Choroid 2. A Light Microscopic Study of Late Stage after Photocoagulation" Acta Soc. Ophthalmol. Jpn.90(2). 283-290 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Naoko Katoh, Hiroshi Ohkuma, Takashi Itagaki, Kazuya Yamagishi, Masanobu Uyama: "A Comparative Study of Effects of Photocoabulation with the Argon Blue-Green and Krypton Red Lasers on the Retina and Choroid III. A Scanning Electron Microscopic Study of the Choroidal Vascular Casts" Acta Soc. Ophthalmol. Jpn.90(6). 898-907 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Kazuya Yamagishi, Hiroshi Ohkuma, Takashi Itagaki, Naoko Kato, Masanobu Uyama: "Relationship of Subretinal Neovascularization and the Retinal Pigment Epithelium-A Preliminary Report-" The Folia Ophthalmologica Japonica. 36(7). 1154-1157 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Koichiro Miki, Stephen J.Ryan, Hiroshi Ohkuma, Masanobu Uyama: "Study of Choroidal Neovascularization with Fluorescein Angiography and Cast Preparation" Acta Soc. Ophthalmol. Jpn.90(5). 749-756 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Takashi Itagaki, Hiroshi Ohkuma, Kazuya Yamagishi, Naoko Katoh, Masanobu Uyama: "Studies on Experimental Subretinal Neovascularization 3. Comparative Study of Histological and Flurescein Fundus Angiographic Findings" Acta. Soc. Ophthalmol. Jpn.90(10). 1217-1225 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Takashi Itagaki, Hiroshi Ohkuma, Kazuya Yamagishi, Kanji Takahashi, Masanobu Uyama: "Studies on Experimental Subretinal Neovascularizaion -Relationship between New Vessel and Retinal Pigment Epithelium-" Therapeutic Research. 5(4). 665-670 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 板垣隆: Therapeutic Research. 5. 665-670 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 山岸和夫: 日本眼科紀要. 37. 1154-1157 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 三木耕一郎: 日本眼科学会雑誌. 90. 749-756 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 板垣隆: 日本眼科学会雑誌. 90. 1217-1225 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Uyama;Masanobu.Ben Ezva O.;Ryan.S.J.ed: "Ocular Circulation and Neovascularization(Choroidal Neovascularization and the Refinal Pigment Epithelium)" Martinus Nijhoff Publisher, (1987)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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