| Project/Area Number |
61480382
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | TOHOKU UNIVERSITY |
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Principal Investigator |
SANJOU Daisuke (1988) Tohoku University, School of Dentistry, Professor, 歯学部, 教授 (70013943)
小倉 保己 (1986-1987) 東北大学, 歯学部, 教授 (60091667)
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| Co-Investigator(Kenkyū-buntansha) |
OGURA YASUMI Tohoku University, School of Dentistry, Professor, 歯学部, 教授 (60091667)
HIRAFUJI Masahiko Tohoku University, School of Dentistry, Assistant, 歯学部, 助手 (20142987)
三条 大助 東北大学, 歯学部, 教授 (70013943)
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| Project Period (FY) |
1986 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1988: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1987: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1986: ¥5,000,000 (Direct Cost: ¥5,000,000)
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| Keywords | inflammatory mediators / PAF / platelet aggregation / vascular contraction / inflammation of the pulp / adrenaline / pulmonary respiration resistance / 抗アレルギー薬 / 血小板活性因子 / 肺抵抗 / 抗ヒスタミン薬 / 微小循環 / 歯髄の炎症 / 細胞内Ca / 氣道抵抗 / ビタミンB_1関連物質 / オータコイド / 毛細血管透過性 / 歯髄炎 / 神経性炎症 / 筋弛緩薬 |
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| Research Abstract |
Some stimulants evoke easily an inflammatory reactionin the pulp tissue. We have reported that histamine and other inflammatory muediators were detected in the pulp and that may be play a role in the inflammatory process. PAF. a new inflammatory mediator, was studied on the signification in pulpal inflammation.
1. PAF was detected in pulpal tissue of rats. And PAF stimulated PGI_2>TXA_2 release from rat pulppal tissue. The fact suggests that the endothelial celles play a important role.
2. In the arterial smooth muscle, PAF potentiated the contracted reaction toadrenaline. The potentiation was not found in other smooth muscles.
3. In neuronal inflammation ( reciprocal electrical stimulation experiments in the sciatic nerve), PAF did not potentiate the reaction, and it increased thecapillary permeability under the existence of endothelial cells. This also is supported by the fact that in the in vivo nerve-muscle preparation, the relaxant action to anticurare agents is inhibited by pretreatment of PAF.
4. In pulmonary respirationresistance experiments, the increase of tracheal contraction with PAF was antagonized by anti-PAF drugs, and also anti- allergic agents and B_1 related compounds. The pulatelet aggregating activity, howoevor, did not be influenced by theseantagonists. Therefore, the above mentionned results suggest that in the initial inflammatory process in the pulpal tissue, PAF may be play a role of the formation of the prearrangements of inflammatory conditions and that the PAF -induced condition may be very intensify the release and actions of mediators.
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