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Experimental and clinical studies on oncogenesis of salivary glands.

Research Project

Project/Area Number 61480415
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 外科・放射線系歯学
Research InstitutionEhime University

Principal Investigator

TANIOKA Hiroaki  Ehime University School of Medicine, Professor, 医学部, 教授 (10028748)

Co-Investigator(Kenkyū-buntansha) HAMAKAWA Hiroyuki  Ehime University School of Medicine, Lecturer, 医学部附属病院, 講師 (20127905)
NAGATO Toshikazu  Ehime University School of Medicine, Lecturer, 医学部附属病院, 講師 (80084284)
HASHIMOTO Yutaka  Ehime University School of Medicine, Associated Professor, 医学部, 助教授 (30108831)
大野 邦博  愛媛大学, 医学部附属病院, 講師 (00111609)
Project Period (FY) 1986 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥5,700,000 (Direct Cost: ¥5,700,000)
Fiscal Year 1988: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1987: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1986: ¥4,500,000 (Direct Cost: ¥4,500,000)
KeywordsSalivary Glands / Salivary Gland Tumors / Myoepithelial Cells / Pleomorphic Adenoma / Mucoepidermoid Tumors / NBD-phallacidin / アクチンフィラメント / 導管上皮基底細胞 / ケラチン単クローン抗体 / 抗平滑筋ミオシン抗体 / 抗プリケラチン抗体
Research Abstract

70 cases of salivary gland tumors removed surgically in our hospital were stained immunohistochemically. Positive immunostaining for S-100 a was observed in pleomorphic adenoma specifically. Duet-like structure in pleomorphic adenoma retains the function of production of lactoferrin and secretory component in accordance with functional differentiation. This results supported Regezi's bicellular theory on the origin of salivary gland tumor.
The low grade differentiated mucoepidermoid tumor, transplanted subcutaneously to nude mouse, was studied on these histophathological feature. We concluded that mucous secreting cells of mucoepidermoid tumor would be differentiated or transformed from the epidermoid cells and the intermediated cells.
To elucidate the postnatal differentiation of salivary gland cells, rat submandibular gland were examined ultrastructurally and morphometrically. During the development of salivary glands, terminal tubule cells of rat submandibular gland decreased gradually and disappeared almost 6 weeks after birth, acinar cells increased greatly in this period. Ultrastructural finding suggested that terminal tubule cells of salivary gland do not transform into acinar cells. Furthermore, late weaning resulted in marked developmental delay of the gland.
Morphological dfferentiation of myoepitherlial cells of rat sublingual gland was examined by using the fluorescent probe for actin, NBD-phallacidin. In newborn, cells with diffuse fluoresecence occurred around the acini, representing incipient myoepithelial cells. Between 3 and 4 days after birth, actin staining was concentrated in strands which were arranged parallel to the long axis of the cell processes. Myoepithelial cells had developed further by 10 days after birth with an increased number and thickness of their processes. Fully developed myoepithelial cells were found on day 60 after birth. These were stellate and encompassed individual acini.

Report

(4 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • 1986 Annual Research Report

Research Products

(27 results)

All Other

All Publications (27 results)

  • [Publications] 浜川裕之: 日本口腔外科学会雑誌. 32(7). 1109-1120 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 森恵造: 日本口腔科学会雑誌.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 村上通隆: 日本口腔科学会雑誌. 36(2). 333-343 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 長門俊一: 日本口腔科学会雑誌. 37(3). 527-539 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 村上通隆: 日本口腔科学会雑誌. 37(3). 540-547 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 森恵造: 日本口腔科学会雑誌. 37(4). 953-964 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Michitaka,Murakami: Archs Oral Biol. 34(2). 143-145 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 長門俊一: "人体組織学" 朝倉書店, 440 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Hiroyuki,Hamakawa: "Immunohistochemical study on human salivary gland tumors." Jpn. j. oral maxillofac. surg.32:7. 1109-1120 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Keizo,Mori: "Morphological studies of human mucoepidermoid tumor transplanted into nude mouse." J Jpn. Stomatol. Soc.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Michitaka,Murakami: "Three-dimensional architecture of the duct system and intercalated duct myoepithelial cells of exocrine glands including salivary gland." J Jpn. Stomatol. Soc.36:2. 333-343 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Toshikazu,Nagato: "Morphological studies on the rat submandibular gland during postnatal development." J Jpn. Stomatol. Soc.37:3. 527-539 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Michitaka,Murakami: "The morphological differentiation of myoepithelial cells in the rat sublingual gland." J Jpn. Stomatol. Soc.37:3. 540-547 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Keizo,Mori: "Transmission electron microscopic and morphometric studies on the postnatal development of the rat submandibular gland." J Jpn. Stomatol. Soc.37:4. 953-964 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Michitaka,Murakami: "Morphological changes in the myoepithelialcells of the rat sublingual salivary gland during differentiation as shown by the nitrobenzoxadiazole-phallacidin fluorescent method." Archs Oral Biol. 34:2. 143-145 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Toshikazu,Nagato: Human Histology. Asakura Shoten, 440 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 村上通隆: 日本口腔科学会雑誌. 37(3). 540-547 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 長門俊一: 日本口腔科学会雑誌. 37(3). 527-539 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 森恵造: 日本口腔科学会雑誌. 37(4). 953-964 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Michitaka Murakami: Archs Oral Biol. 34(2). 143-145 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 長門俊一: "人体組織学" 朝倉書店, 0-440 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 村上通隆他: 日本口腔科学会雑誌. 36. 333-343 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 長門俊一他: 日本口腔科学会雑誌. 36. 362-384 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 浜川裕之,他: 日本口腔外科学会雑誌. 32. 1109-1120 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Hirofumi Ogase;Hiroaki,Tanioka,et al.: The Journal of Osaka University Dental School. 26. 193-201 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 長門俊一,他: 日本口腟科学会雑誌. 36. 362-384 (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] 村上通隆,長門俊一,谷岡博昭: 日本口腟科学雑誌. 36. 337-343 (1987)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-30   Modified: 2016-04-21  

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