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The role of genes associated with cell growth in proliferating diseases

Research Project

Project/Area Number 61480434
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 医学一般
Research InstitutionHokkaido University.

Principal Investigator

KUZUMAKI Noboru  Hokkaido University School of Medicine, 医学部, 教授 (80091445)

Project Period (FY) 1986 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥7,400,000 (Direct Cost: ¥7,400,000)
Fiscal Year 1987: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1986: ¥6,900,000 (Direct Cost: ¥6,900,000)
KeywordsPsoriasis / oncogenes / oncogene products / monoclonal antibody / mRNA / マウス形質細胞腫 / 正常復帰細胞株 / 皮膚腫瘍
Research Abstract

Expressions of several protooncogenes related with cell growth were examined in psoriatic tissues comparing those in normal skin tissues using monoclonal antibody and Northern blotting techuiques. Immunofluorescence studies using monoclonal antibody rp35 reacted with ras p21 revealed that only based layers of epidermis were stained in normal skin, while whole layers of epidermis were stained in psoriatic tissues, sugges ting overproduction of ras p21 in this disease. Northern blotting techniques with poly a(+) mRNA derived from psoriatic tissues and normal skin demonstrated that levels of fos and myc transcripts were decreased, while that of K-ras transcript was increased in psoriatic tissues in comparison with those in normal skins. All these data suggest association of protooncogenes with pathogenesis of psoriasis.

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] Kobayashi, H.: J. Investing. Dermatol.88. 499 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Kuzumaki, N.: 日本研究皮膚科学会年次学術大会抄録集. 12. 99 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Yasuda, H.: 日本研究皮膚科学会年次学術大会抄録集. 12. 111 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Kobayashi, H.: 日本研究皮膚科学会年次学術大会抄録集. 12. 111-112 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Ogiso, Y.: J. Investig. Dermatol.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Kobayashi, H.: Archives of Dermatological Research.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Kobayashi,H.: "Immunohistochemical analysis of normal tissues and tumors in human skin with anti-ras oncogene product p21 monoclonal antibodies" J. Investig. Dermatol.88. 499 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Kuzumaki,N.: "Oncogenes and skin tumors" Proc. Jpn. Soc. Invest. Dermatol.In press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Yasuda,H.: "Immunohistochemical analysis of ras oncogene product in psoriatic and normal epidermis with anti-ras oncogene product monoclonal antibldy" Proc. Jpn. Soc. Invest. Dermatol.In press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Kobayashi,H.: "Oncogene expression in psoriatic epidermis" Proc. Jpn. Soc. Invest. Dermatol.In press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Ogiso,Y: "Expression of proto-oncogenes in normal and tumor tissues of human skin" J. Investig. Dermatol.In press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Kuzumaki,N.: J.Natl.Cancer Inst.77. 1273-1279 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 堂坂弘俊: 医学のあゆみ. 138. 781-782 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 葛巻暹: 日本癌学会総会記事. 45. 501 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 小木曾嘉文: 日本癌学会総会記事. 45. 518 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 近藤信夫: Oncologia. 20(2). 113-118 (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] Oikawa,T: Int.J.Cancer.

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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