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Immunochemical studies of the mammalian egg coat and immunosuppressive roles of decidual cells in implantation

Research Project

Project/Area Number 61480435
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 医学一般
Research InstitutionUniversity of Tokyo

Principal Investigator

MORI Tsuneatsu  Dept.Immunol.,Institute of medical science,Univ.Tokyo, 医科学研究所, 助教授 (40012760)

Co-Investigator(Kenkyū-buntansha) NODA Yoichi  Dept.Gyn.Obstet.,Faculty of medicine,Univ.Kyoto, 医学部産婦人科, 助教授 (50115911)
狩野 恭一  東京大学, 医科学研究所, 教授 (80152825)
刈米 アイ  東京大学, 医科学研究所, 教務職員 (50114450)
Project Period (FY) 1986 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 1988: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1987: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1986: ¥2,500,000 (Direct Cost: ¥2,500,000)
KeywordsZona pellucida / Decidual cell / 免疫抑制作用 / 胱溶膜細胞 / 精子レセプター / 子宮内脱落膜細胞 / 免疫抑制物質 / 発癌遺伝子
Research Abstract

In this project, molecular mechanisms, which promoted the species specific and/or allogeneic recognition between sperm and egg,were investigated. On the other hand, implantation, which was the naturally succeeded semiallograft, was studied on the immunosuppressive functions of decidual tissues. By using the monoclonal technology, the monoclonal antibody detecting the cross reactive portion between human and porcine zona pellucida(ZP) was obtained and its portion was chemically defined as protein nature. The carbohydrate structure of ZP specifically binding with porcine sperms was analysed and then finished in neutral oligosaccharides. Further study on its acidic oligosaccharides was started. The interaction of class II MHC molecules on sperm and L3T4 like molecules on egg vitellus in mouse system was strongly suggested as the mechanisms for the allogeneic recognition in both gamates.
It was revealed that supernatant derived from human decidual cell line demonstrated the activity of immunosuppression but also the inhibition of tumor cell line growth and the enhancement of mouse embryonal development in vitro. The chemical analysis and purification corresponding with biological assay are now going under study.

Report

(4 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • 1986 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] Mori,T.: J.Reprod.Immunol.8. 1-11 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Mori,T.: Antibodies:Protective,Destructive,and Regulatory Role Milgrom,F.et al.eds.Karger Basel. 382-388 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Tatsumi,K.: A.J.Reprod.Immunol.and Microbiol.13. 87-92 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Mori,T.: Proc.Jap.Soc.Immunol.17. 743 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Mori,E.: Eur.J.Obstet.Gyn.and Reprod.(1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Fukuda,A.: J.in vitro Fertil.and Embryotransfer. (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Mori,T.: "Antibodies to zona pellucida and human infertility,in perspective in immunoreproduction;conception and contraception." Hemisphere Publishing Corporation, 160-176 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Mori,T.: "Clinical significance of autoantibodies to the zona pellucida,in the mammalian egg coat.Dietl J.ed." SpringerーVerlag, 111-127 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Mori,T.: "Roles of major histocompatibility antigen (class II) in fertilization" Proc. Jap. Soc. Immunol.17. 743 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Tatsumi,K.: "Immunoregulatory factor released from a cell line derived from human decidual tissue" A. J. Reprod. Immunol. and Microbiol.13. 87-92 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Mori,E.: "On the epitopes of porcine zona pellucida recognized by two monoclonal antibodies" Eur. J. Obstet. Gyn. and Reprod.in press. (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Fukuda,A.: "Supernatants of mixed lymphocyte culture and decidual cell line culture on mouse embryo development in vitro." J. in vitro Fertil. and Embryotransfer. in press. (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Mori,T.: Antibodies to zona pellucida and human infertility ;Perspectives in immunoreproduction-Conception and contraception.Hemisphere Publishing, 160-176 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Mori,E;Noda,Y;Mori,Ta.Mori,T.: Eur.J.Obestet.Gyn.and Reprod.(1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Fukuda,A;Mori,T;Mori,Tatsumi,K;Kanzaki,H;Mori,Ta: J.in vitro Fertil.and Embryotransfer. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Mori,Ta;Noda,Y;Takai,I;Mori,T.: "Antibodies to zona pellucida and human infertility in Perspectives in immunoreproduction;conception and contraception.Mathur,S.and Frederics,C.M.eds." Hemisphere Publishing Corporation, 160-176 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Mori,Ta.;Ida,Y.;Noda,Y.;Matumoto,H.;Mori,T.;Mori,E.: "Clinical significance of autoantibodies to the zonapellucida in the mammalian egg coat.Dietl J.ed." Springer-Verlag, 111-127 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Tatsumi.K: A.J.Reprod.Immunol.and Microbiol.13. 87-92 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Irahara.M: Immunobiol.174. 190-199 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Mori.E: J.Reprod.Immunol.

    • Related Report
      1987 Annual Research Report
  • [Publications] Mori.E: J.Immunol.

    • Related Report
      1987 Annual Research Report
  • [Publications] Mori.T;Yamauchi.K: "Genetic Manipulation of the Early Mammalian Embryo" 近代出版, 298 (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] Mori.T;Yamauchi.K;Iwakura.Y;Toyoda.Y: "Manipulating the Mouse Embryo" 近代出版, 332 (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] Shigyo,Y.: Immunol,In vest.15. 23-33 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Mori,T.: J.Natl.Cancer Inst.77. 115-120 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Tatsumi,K.: A.J.Reprod.Immunol.and Microbiol.(1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] Mori,E.: Proc.Jap.Can.Assoc.The 45th Annual Meeting. 45. (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Mori,E.: J.Reprod.Immunol.

    • Related Report
      1986 Annual Research Report
  • [Publications] Mori.T.: "Antibodies to the zona pellucida in relation to human fereility (Perspectives in Immuncreproduction and contra ception)" Hemisthere Publishing corporation Washington D.C.U.S.A, (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] Mori,T.: "Immunobiological and chemical stndis on forssman antigen in animal and human tumors(Proc.of the 【VIII】 th Tutenyitioual Conference on Labslled Artibalis)" Clniversity of Tokyo Rress Tokyo,Japan, (1987)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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