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DEVELOPMENTAL GENETICS IN TESTICULAR TERATOCARCINOGENESIS AND GERM CELL DEFICIENCY CAUSED BY THE GENE ter IN MICE.

Research Project

Project/Area Number 61540516
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 動物発生・生理学
Research InstitutionSHIZUOKA UNIVERSITY

Principal Investigator

NOGUCHI Motoko  BIOLOGICAL INSTITUTE, FACULTY OF SCIENCE, SHIZUOKA UNIVERSITY, 理学部, 助教授 (40021951)

Project Period (FY) 1986 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1987: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1986: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsTestcular teratomas / Teratocarcinogenesis / Primordial germ cells / Germ cell deficiency / Recessive mutant gene / teratoma(ter) / 劣性突然変異遺伝子teratoma(ter) / terコンジェニック系統 / 精巣性奇形腫高発系統マウス / Sv-ter系統マウス / 劣性突然変異遺伝子ter / 生殖細胞腫瘍化
Research Abstract

TESTICULAR TERATOMAS IN MICE ARE CONGENITAL ABNORMALITIES ORIGINATING WITHIN SEMINIFEROUS TUBULES IN FETAL TESTES FROM SINGLE PRIMORDIAL GERM CELLS(PGCS). RECENTLY NOGUCHI AND NOGUCHI FOUND THAT THE SINGLE RECESSIVE MUTANT GENE ter CAUSES GERM CELL DEFICIENCY, ACCOMPANIED BY A HIGH INCIDENCE OF TESTICULAR TERATOMAS IN ter HOMOZYGOUS MICE IN 129/Sv-ter STRAIN (JNCI,75,385,1985). IN THIS RESEARCH,THE EXPRESSION OF THE GENE ter IN GERM CELL DEFICIENCY AND TESTICULAR TERATOCARCINOGENESIS WAS ANALYSED FROM THE VIEWPOINT OF DEVELOPMENTAL GENETICS.
1. IN ORDER TO ESTABLISH THE DEVELOPMENTAL BASIS OF STERILITY AND TESTICULAR TERATOCARCINOGENESIS IN ter/ter MICE, THE NUMBER, LOCATION AND MORPHOLOGY OF PGCS WERE EXAMINED IN 8.5-12.5 DAYS EMBRYOS FROM MATING OF +/ter x +/ter AND+/+ x +/+. IT WAS SHOWN THAT THE GENE ter CAUSES EXTRA-GONADAL PGCS DEFICIENCY,NOT ACCOMPANIED BY EXTRACONADAL TERATOCARCINOGENESIS IN ter HOMOZYGOTES IN9.5-12.5 DAYS EMBRYOS IN 129/Sv-ter MICE.
2. IN ORDER TO EXAMINE THE INFLUENCE OF A GENETIC BACKGROUND ON THE ter ACTION, THE GENE ter WAS INTRODUCED ONTO C57BL/6J GENETIC BACKGROUND BY BACKCOSSING FOR 9 GENERATIONS. IT WAS CONCLUDED THAT THE GENE ter ON C57BL/6J GENETIC BACKGROUND IN ter CONGENIC MICE CAUSES GERM CELL DEFICIENCY IN ter HOMOZYGOTES AND THAT GENE(S) OTHER THAN ter IN 129/Sv ARE INVOLVED IN DETERMINING SUSCEPTIBILITY TO TESTICULAR TERATOCARCINOGENESIS IN PGCS.

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] MOTOKO NOGUCHI: ZOOL.SCI.4. 1042 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 野口武彦,村松喬編,野口基子: "「マウスのテラトーマ」マウステラトーマの生物学" 理工学社, 40 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 野口武彦,村松喬編,野口基子: "「マウスのテラトーマ」テラトカルシノーマの誘発と継代移植の方法" 理工学社, 9 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] MOTOKO NOGUCHI: "THE MUTANT GENE ter CAUSES GERM CELL DEFICIENCY, NOT ACCOMPANIED BY TESTICULAR TERATOCARCINOGENESIS, IN A C57BL/6J GENETIC BACKGROUND" IN MICE (ABSTRACT). ZOOL.SCI.4. 1042- (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] MOTOKO NOGUCHI: "PRIMORDIAL GERM CELL DEFICIENCY, INDUCED BY THE GENE ter IN 129/Sv-ter MICE"

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] MOTOKO NOGUCHI: "GERM CELL DEFICIENCY, NOT ACCOMPANIED BY TESTICULAR TERATOCARCINOGENESIS IN ter CONGENIC MICE"

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] MOTOKO NOGUCHI: BIOLOGY OF MOUSE TERATOMA IN" TERATOMA IN MICE" EDITED BY, NOGUCHI,T. AND MURAMATSU,T.RIKOUGAKUSHA, 3.1-3.40 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] MOTOKO NOGUCHI: METHODS OF EXPERIMENTAL PRODUCTION AND TRANSPLANTATION OF MOUSE TERATOCARCINOMA IN" TERATOMA IN MICE" EDITED BY,NOGUCHI,T. AND MURAMATSU,T.RIKOUGAKUSHA, 7.1-7.9 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Noguchi,Motoko: Development.

    • Related Report
      1986 Annual Research Report
  • [Publications] Noguchi,Motoko: J.N.C.I.

    • Related Report
      1986 Annual Research Report
  • [Publications] 野口基子著,野口武彦,村松喬 編: "マウステラトーマの生物学「マウスのテラトーマ」EC細胞による哺乳動物の実験発生学" 理工学社, 40 (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] 野口基子著,野口武彦,村松喬 編: "テラトカルシノーマの誘発と継代移植の方法「マウスのテラトーマ」" 理工学社, 9 (1987)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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