Studies on the host resistance to infection with larval cyclophyllidean cestodes
| Project/Area Number |
61560331
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
基礎獣医学
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| Research Institution | Hokkaido University |
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Principal Investigator |
OKU Yuzaburo Faculty of Veterinary Medicine・Instructor, 獣医学部, 助手 (60133716)
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| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Munehiro Faculty of Veterinary Medicine・Instructor, 獣医学部, 助手 (70177096)
KAMITA Masao Faculty of Veterynary Medicine・Associate Professor, 獣医学部, 助教授 (30081665)
OHBAYASHI Masashi Faculty of Veterinary Medicine・Professor, 獣医学部, 教授 (60001517)
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| Project Period (FY) |
1986 – 1987
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| Project Status |
Completed (Fiscal Year 1987)
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| Budget Amount *help |
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1987: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1986: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | Life cycle / Innate resistance / Echinococcus multilocularis / Taenia hydatigena / Taenia taeniaeformis / Taenia hydatigena / Taenia crassiceps / 肥満細胞 / 円葉条虫 |
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| Research Abstract |
1. Infectivity of three isolates of Taenia taeniaeformis (Hokkaido-Rattus, Malaysia-Rattus and Hokkaido-Clethrionomys isolates) varied in some wild and experimental rodents, especially rat and Clethrionomys rufocanus. 2. The rodents, which were resistant to oral infection with eggs of Taenia hydatigena, were susceptible to intraperitoneal inoculation of immature cysticercus. 3. Significant difference was observed in susceptibility of some experimental animals and C. rufocanus to oral infection of eggs or to intraperitoneal inoculation of larvae of Echinococcus multilocularis and Taenia crassiceps. 4. In cortisone-treated, X-ray-irradiated and cyclophosphamide-treated mice, the larvae of T. taeniaeformis survived for longer period than that in cobra venom factor-treated, carrageenan-treated and control mice. 5. Egg of E. multilocularis is very danger to breeders, so dogs were operated surgically, so a separated small intestine were produced in the perotoneal cavity of the dog. In the separated small intestine, the injected protoscolices of E. multilocularis did not developed, and were dead in short period. 6. Gorden hamsters were infected orally with larvae of E. multilocularis and T. crassiceps. In the small intestine of the host, E. multilocularis were developed, and mature segument were observed. T. crassiceps produced eggs in hamsters. 7. Experiments using inbred mouse and in vitro experiments are carrying out.
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Report
(2 results)
Research Products
(2 results)
