| Budget Amount *help |
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1987: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1986: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Research Abstract |
Our knowledge on morphology and pathogenesis of glomerulonephritis(GN) in domestic animals is still fragmentory. The present study was undertaken to clarify the pathological entities of GN in dogs, chickens and pigs.
1. Dogs
The kidneys of 147 dogs autopsied were examined. Of 147 cases, 121 dogs showed GN. Among these, 55 exhibited mesangioproliferative GN, 34 membranoproliferative GN, and 32 membranous GN. The glomerular change progressed with an increase of age and all dogs older than 5 years were affected with GN. The dogs infestated with Dirofilaria immitis were affected with membranous and membranoproliferative GN more frequently than the dogs without the infetation.
2. Chickens
The kidneys of 18, 339-504 days old layers were examined. All the kidneys showed diffuse mesangioproliferative GN. A deposition of IgG in mesangial matrix was seen in all cases, but the deposition of immuine complex was considered to be etiologically unrelated with GN.
3. Pigs
The kidneys of 1292, apparently healthy rearing pigs were examined. GN appeared in 1177 cases. Of these glomerular changes, intratubular proliferation predominated in 7 pigs and mesangioproliferative changes in 1110 pigs. The glomerular changes frequently coexisted and were considered as different stages of intratubular proliferative GN. Hemolytic streptococcus is usual habitant f swine tonsilla and the tonsillitis due to the bacteria was considered to be a possible factor for the development of swine GN
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