| Project/Area Number |
61560352
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied veterinary science
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| Research Institution | Iwate University |
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Principal Investigator |
MURAKAMI Daizo (1987-1988) Faculty of Agriculture, Iwate University,Professor, 農学部, 教授 (00003731)
内藤 善久 (1986) 岩手大, 農学部, 助教授 (40003785)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Reeko Faculty of Agriculture, Iwate University,Associate Prof., 農学部, 助手 (80142892)
NAITO Yoshihisa Faculty of Agriculture, Iwate University,Associate Prof., 農学部, 助教授 (40003785)
村上 大蔵 岩手大学, 農学部, 教授 (00003731)
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| Project Period (FY) |
1986 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1988: ¥100,000 (Direct Cost: ¥100,000)
Fiscal Year 1987: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1986: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | Parturient Paresis / Dairy cow / Hypocalcemia / Vitamin D / Ca Metabolism / Ca代謝 / PTH / ビタミンD / 妊娠ラット / ^<45>Caの動態 / 分娩性低Ca血症 / ビタミンD_3 / Ca動態 / カルシトニン / 分娩性起立不能症 / 乳牛;1,25【(OH)_2】D / 25OHD / 乳牛の代謝病 |
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| Research Abstract |
Parturient paresis is a metabolic disorder occurring in association with parturition indairy cows. This disease is closely related to the initiation of lactation and the intestinal absorption of calcium(Ca), and is characterized by a rapid decline in the concentrations of serum Ca and inorganic phosphorus(Pi). Therefore, the present study has been carried out to determine the etiology of parturient paresis and the efficacy of 1 (OH)D_3 as prophylactic of this disease under clinical and experimental conditions in cows and rats. 1. A total of 23 cows fallen into parturient paresis wihtin 2 days after parturition were examined. These results suggested that most cases of parturient paresis might be caused by hypocalcemia, and that the plasma 1,25(OH)_2D_3 and PTH levels might increaes in proportion to the decrease in plasma Ca concentration. 2. Ten pregnant Holstein-Friesian cows were divided into control and terated groups, each consisting of 5 cows. Treated cows were injected omce with 500 g of 1 (OH)D_3 at 8 days to 6 hrs to before parturition. Three out of 5 treated cows were injected 1 (OH)D_3 at 2 days to 6 hrs before calving and showed the distinct increase of plasma 1.25(OH)_2D_3 concentration at parturition, which inhibited the decrement of plasma Ca. 3. Fourteen Jersey cows were divided into two groups, a control group and treated group that was injected with 1 (OH)D_3 11-28 hr before calving. These results suggested that the production of 1.25(OH)_2D_3 in the kidney plays an important role in the invention of parturient paresis and that injection of 1 (OH)D_3 was appropriate for the prevention of this disease.
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