| Project/Area Number |
61570003
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Gunma University |
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Principal Investigator |
INOUE Kinji Gunma University, Institute of Endocrinology, 内分泌研究所, 助教授 (50091963)
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| Co-Investigator(Kenkyū-buntansha) |
谷口 豊 群馬大学, 内分泌研究所, 助手 (70125863)
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| Project Period (FY) |
1986 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1988: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1987: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1986: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | ANTERIOR PITUITARY / STRIATE MUSCLE / FOLLICULO*STELLATE CELL / フィブロネクチン / 筋繊維 / ラトケ嚢 / 細胞増殖 / 分化 / カルシウム / S-100蛋白 / 機能 / ラトケ嚢遺残腔辺縁上皮細胞 |
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| Research Abstract |
In order to reveal the function and differentiation of folliculo-stellate cell in the rat anterior pituitary gland, the morphological studies were performed. The main finding of this study was the observation of striated muscle fibers in the pituitary gland grafts transplanted beneath the kidney capsule. These ectopic differentiated striated muscle fibers were closely associated with folliculo-stellate cells, including the possibility of folliculo-stellate cell have a potential of differentiation to striated muscle fibers.
The histochemical studies revealed that follicul/-stellate cell have extremely elongated cell processes which wrap around the neighboring glandular cells. Ca-depend ATPase localized around these cell processes and follicle lumen, suggesting folliculo-stellate cell may control the secretory function of neighboring glandular cells through the regulation of calcium transport. the immunohistochemical studies revealed that folliculo-stellate cell contain fibronectin however, the biological significance of fibronectin in folliculo-stellate cell is unknown.
In conclusion, it is considered that folliculo-stellate cell is a multi-functional cell which control the neighboring glandular cell in anterior pituitary gland.
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