| Project/Area Number |
61570083
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
環境生理学(含体力医学･栄養生理学)
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| Research Institution | Niigata University |
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Principal Investigator |
HIRANO Tetsuo (1987) Instructor, Niigata University, 医学部, 講師 (50092721)
新島 旭 (1986) 新大, 医学部, 教授 (20018287)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUDA AKIKO Assistant, Niigata University, 医学部, 助手 (20018328)
NIIJIMA Akira Emeritus Professor, Niigata University, 医学部, 名誉教授 (20018287)
平野 鉄雄 新潟大学, 医学部, 助手 (50092721)
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| Project Period (FY) |
1986 – 1987
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| Project Status |
Completed (Fiscal Year 1987)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1987: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1986: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | Gastrin / CCK / Somatostatin / ANP / Autonomic nervous system / 迷走神経 / 遠心性活動 / ペンタガストリン / CCK-8 / 迷走神経遠心性活動 |
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| Research Abstract |
Under anaesthesia (urethane 500-800 mg/kg and chloralose 40-70mg/kg), effect of i.v. administration of pentagastrin, CCK-8, somatostatin and ANP on efferent activity of autonomic nerve was observed in rats.
An increase in activity was observed in gastric branch of vagus nerve following injection of pentagastrin, and that in pancreatic branch of vagus nerve after injection of CCK-8.A decrease in activity was observed in gastric, hepatic and pancreatic branch of vagus nerve following application of somatostation or ANP. ANP application also caused a suppression on activity of adrenal and renal sympathetic efferents. The smallest effective dose of these substances was 100pg.
In decerebrated preparations no change in efferent activity was observed after administrations of these substances.
The results indicate that neuropeptides such as pentagastrin, CCK-8, somatostatin and ANP released into venous circulation modulate autonomic outflows through hypothalamic neuronal networks surrounding with insufficient blood-brain barrier.
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