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Physiological Regulation of Cardiac Alpha Adrenergic Receptors

Research Project

Project/Area Number 61570098
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field General pharmacology
Research InstitutionYamanashi Medical College

Principal Investigator

HASHIMOTO Keitaro  Yamanashi Medical College, 医学部, 教授 (10004665)

Co-Investigator(Kenkyū-buntansha) TSUJIMOTO Gozoh  Yamanashi Medical College, 医学部, 助手 (80172013)
Project Period (FY) 1986 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1987: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1986: ¥1,600,000 (Direct Cost: ¥1,600,000)
KeywordsHeart / -adrenergic receptors / Aging / Hyperthyroidism / 褐色細胞腫 / α受容体 / 単離心筋細胞 / 心拍数
Research Abstract

In the present work, we first characterized alpha-1 adrenergic receptors in rat cardiac membrane preparation, utilizing alpha-1 selective antagonist [^3H]prazosin as a radioligand. Then, the in vivo regulation of these receptors in a variety of physiologic and pathophysiological situations including aging,thyroid hormone and pheochromocytoma was studied Comparing young (2 month-old) and older (12 month-old)rats, we found that there was an age-related decreae in the number of myocardial alpha-1 receptors. With thyroid hormone treatment, the density of ventricular alpha-1 receptors was found to be further reduced even in the older rats, suggesting that thyroid hormone and aging have different influences on the cardiac alpha-1 receptors and these two physiological variables are independently interrelated Next, we have examined the consequences of prolonged stimulation of the cardiac alpha receptors in a rat model harboring pheochromocytoma. A marked down-regulation of alpha-1 receptors was found in the hearts of pheochromocytoma rats.without any significant change in the affinities of these receptors for the circulating catecholamine. In summary,these studies cleary demonstrate that the cardiac alpha adrenergic receptors can be dynamically regulated in vivo like cardiac beta receptors.

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] G.Tsujimoto,et al.: Heart and Vessels. 1. 152-157 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] G.Tsujimoto,et al.: Japan.J.Pharmacol.44. 437-445 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] G.Tsujimoto,et al.: Am.J.Physiol. 21. H513-H520 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] G.Tsujimoto,et al.: Circ.Res.61. 86-98 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] G.Tsujimoto,et al.: J.Pharmacol.Exp.ther.242. 637-645 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] G. Tsujimoto, et al.: "Effects of pheochromocytoma on cardiovascular alpha adrenergic receptor system" Heart and Vessels. 1. 152-157 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] G. Tsujimoto, et al.: "Effects of triiodo-1-thyronine (T_3)-induced hyperthyroidism on the cardiovasular alpha-adrenoceptor system in young and older rats" Japan. J. Pharmacol.44. 437-445 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] G. Tsujimoto, et al.: "Effects of thyroid hormone on -adrenergic responsiveness of aging cardiovascular systems" Am. J. Physiol.21. H513-H520 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] G. Tsujimoto, et al.: "Desensitization of postjunctional _1-and _2-adrenergic receptor-mediated vasopressor responses in rat harboring pheochromocytoma" Circ. Res.61. 86-98 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] G. Tsujimoto, et al.: "Characterization of vasopressor response to sympathetic stimulation in the pithed rat: Differential regulation of neuronally stimulated and blood-borne catecholamine-stimulated pressor responses in rats harboring pheochromocytoma" J. Pharmacol. Exp. Ther.242. 637-645 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary

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Published: 1987-03-31   Modified: 2016-04-21  

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