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Intracellular action of accumulated catecholamine in rat heart.

Research Project

Project/Area Number 61570101
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field General pharmacology
Research InstitutionKyoto University

Principal Investigator

KURAHASHI Kazuyoshi  Radioisotope Research Center, Kyoto University, Associate Professc, 放射性同位元素総合センター, 助教授 (10025653)

Project Period (FY) 1986 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1987: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1986: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsIntracellularly accumulated catecholamine / C-AMP / Lactate / 乳酸産生 / カテコラミン / 心筋細胞内蓄積 / 細胞内受容体 / 心室細動 / 【Ca^(2+)】括抗薬 / 【α_1】-遮断薬
Research Abstract

We have reported that the increase in extraneuronal accumulation of catecholamine in rat heart increases the incidence of ventricullar fibrillation. The present experiments were undertaken to investigate whether the increase in extraneuronal accumulation of isoprenaline affects cyclic AMP production and lactate production, and to examine effect of ischemia on the extraneuronal uptake mechanism. In perfused rat hearts, the increase in intracellular accumulation of isoprenaline under COMT inhibition did not enhance the cyclic AMP production in the heart. The lactate production was increased by the enhancement of accumulation of isoprenaline and was decreased by the reduction of it. The extraneuronal uptake mechanism was not inhibited by glucose-deprivation or anoxic conditions, and was inhibited by both of them.
From these results, it was concluded that the intracellularly accumulated amine may inhibit adenylate cyclase system but enhance glycolysis in rat heart, and it was suggested that ischemia may inhibit the extraneuronal uptake mechanism.

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] Magaribuchi,T.: Naunyn-Schmiedeberg´s Arch pharmacol. 335. 123-128 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Inoue,M.: J.Pharmacol.Exp.Ther.242. 1086-1089 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Inoue,M.: Eur.J.Pharmacol.141. 203-207 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Inoue,M.: Eur.J.Pharmacol.143. 251-257 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Inoue,M.: Japan J.Pharmacol.46. 83-85 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Magaribuchi, T.: "Effects of extraneuronal uptake inhibitors on the positive chronotropic response to isoprenaline and on the accumulation of isoprenaline in perfused rat heart after inhibition of catechol-O-methyl transferase." Naunyn-Schmiedeberg's Arch Pharmacol. 335. 123-128 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Inoue, M.: "Impairment of extraneuronal O-methylating system of isoproterenol by stop-flow ischemia in the perfused rat heart." J. Pharmacol. Exp Ther.242. 1086-1089 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Inoue, M.: "Effects of anoxia and ischemia on uptake_2 of catecholamines in perfused rat heart." Eur. J. Pharmacol.141. 203-207 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Inoue, M.: "Noradrenaline turnover after left coronary artery ligation in rat heart." Eur. J. Pharmacol.143. 251-257 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Inoue, M.: "Involvement of uptake_<> mechanism in inactivation f noradrenaline released by tyramine under anoxic conditions in perfused rat heart." Japan J. Pharmacol.46. 83-85 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Inoue, M.: "Isoprenaline reduces lactate accumulation of isolated rat heart in absolute ischemia."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Inoue, M.: "Intracellular accumulation of isoprenaline enhances glycolysis in perfused ratheart."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Kurahashi, K: "Extraneuronal accumulation of isoproterenol suppresses C-AMP production in perfused rat heart through intracellular -adrenoceptor activation."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] K.Sono: Naunyn Schmiedeberg´s Arch Pharmacol.334. 145-148 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] T.Magaribuchii: Naunyn Schemiedeberg´s Arch Pharmacol.335. 123-128 (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] Y.Akimoto: Japan J.Pharmacol.40(Supp.). 238 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] T.Magaribuchi: Japan.J.Pharmacol.40(Supp.). 98 (1986)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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