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Neuropharmacological study on excitatory amino acid receptors in hippocampus

Research Project

Project/Area Number 61570103
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field General pharmacology
Research InstitutionFaculty of Pharmaceutical Sciences, Osaka University

Principal Investigator

BABA Akemichi  Fac. Pharm. Sci., Osaka Univ. Assistant Prof., 薬学部, 助教授 (70107100)

Co-Investigator(Kenkyū-buntansha) IWATA Heitaroh  Fac. Pharm. Sci., Osaka Univ., Assistant Prof., 薬学部, 教授 (30028823)
Project Period (FY) 1986 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1987: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1986: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsHippocampus / Excitatory amino acid receptors / chloride transport / cyclic AMP / Zn結合蛋白 / 興奮性アミノ酸 / システインスルフィン酸 / 受容体
Research Abstract

1. Excitatory amino acid receptor binding:
Glutamate (glu) cysteine sulfinate, excitatory amino acid agonists, have different binding sites in synaptic membranes of rat. Cl-Dependent glu binding sites are related,to Cl-dependent sequestration of glu. Depolarization of brain slices are accompanied by a specific increase in the Cl-dependent binding sites for glu. Furthemore, cysteic acid, an excitatory sulfur amino acid, is a specific ligand for this Cl-dependent glu binding site.
2. Cyclic AMP formation in hippocampal slices:
Excitatory amino acids. such as glu and cysteine sulfinate, markedly enhance the formation of cyclic AMP through their own receptors in hippocampus. Complete dependency on Cl ion indicates that Cl transport is essential for excitatory amino acid receptors-mediated stimulation of cyclic AMP formation.
3. Release of amino acid neurotransmitter:
Enhancement of GAGA release by excitatory amino acids is mediated by excitatory amino acid receptors. Insulim and Zn ion specifically attenuated the stimulatory effect of cysteine sulfinate on GABA release. In addition, Zn ion specifically inhibited the release of glu from the preloaded hippocampal slices. Zn ion localized in the soluble fraction of hippocampus as proteinbound form. Excitatory amino acids, especially quisqualate, stimulated the release of Zn ion from the binding proteins.

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] A.Baba;Y.Koyama;H.Morimoto;H,Iwata: "The biology of taurine"(R.J.Huxtable F.Franconi & A.Giotti eds.),Plenum Pub.Corp.New York. 319-324 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] A.Baba: Japan.J.Pharmacol.43. 1-7 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] A.Baba;Y.Nishiuchi;A.Uemura;H.Iwata: J.Neurochem.(1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] A.Baba;Y.Nishiuchi;A.Uemmura;H.Iwata: J.Pharmacol.Exp.Ther.245. (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] H.Iwata;Y.Koyama;A.Baba: J.Neurochem.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] H.Iwata;Y.Kihara:Y.Koyama;T.Ishihara;A.Baba: Experientia.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] A. Baba, Y. Koyama, H. Morimoto, H. Iwata: "Neurochemical characterization of excitatory amino acid receptor in hippocampus" The biology of taurine (R.J. Huxtable., F. Franconi, A. Giotti eds.), Plenum Press, New York. 319-324 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] A. Baba: "Neurochemical characterization of cysteine sulfinic acid, an excitatory amino acid in hippocampus" Japan. J. Pharmacol.43. 1-7 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] A.Baba, Y. Nishiuchi, A. Uemura, H. Iwata: "Inhibition by forskolin of excitatory amino acid-induced accumulation of cyclic AMP in guinea pig hippocampal slices" J. Neurochem.in press (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] A. Baba., Y. Nishiuchi, A. Uemura, H. Iwata: "Mechanism of excitatory amino acid-induced accumulation of cyclic AMP in hippocampal slices: Role of extracellular chloride" J. Pharmacol. Exp. Ther.245. (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] H. Iwata, Y. Koyama, A. Baba: "Depolarization increases chloride-dependent glutamate sequestration in synaptic membranes of rat cerebral cortex" J. Neurochem.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] A.Baba: Japan.J.Pharmacol.43. 1-7 (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] A.Baba;Y.Koyama;H.Morimoto;H.Iwata: Taurine and related compounds,. (1987)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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