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Pathogenesis of spontaneous hepatitis in LEC rats with combined immunodeficiency

Research Project

Project/Area Number 61570163
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Experimental pathology
Research InstitutionHokkaido University

Principal Investigator

TAKEICHI Noritoshi  Hokkaido University, School of Medicine, 医学部, 助教授 (40002133)

Project Period (FY) 1986 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1987: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1986: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsLEC rats / Spontaneous hepatitis / Combined immunodificieney / Immunoglobulin / マクロファージ / 肝炎モデル動物 / 劇症肝炎 / 肝癌
Research Abstract

We investigated LEC rats which spontaneously develop hepatitis to findout the cause immunopathologically, in comparison with non hepatitis LEA rats.
Wet weight of spleen and thymus of 6-week old LEC rats was significantly lighter then that of LEA rat of the same age.
Serum IgG level in LEC rats remained markedly low after the age of 4 weeks, and IgG antibody form ation to SRBC as detected by plaque assay was also significantly suppressed. Furthermore, genetic studies of crossing hybrids of LEA and LEC rats revealed that there was a close correlation between development of hepatitis and lower levels of IgG: no hepatitis case was found in F_1 group which had relatively high IgG levels, but many in F_2 and backcross groups which had lower IgG levels. On the other hand, IgG and IgM antibody formation was suppressed, though serum IgM level was normal or rather increased.
Blastgenic response of spleen cells to PHA and Con A was much more suppressed in LEC rats than in LEA rats.
Cytostatic activity of intraperitoneal macrophage against tumor cells was more evident inLEC rats than in LEA rats, but there was no difference inNK activity between the two rat strains. From these results, it is speculated that spontaneously hepatitisdeveloping LEC rats possess T and B cell deficiency (combined immunodeficiency) and that the increase of macrophage and NK cell activitiesare linked to the cause of developing hepatitis.

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] Matsumoto,K.et al: Transplantation Prpceedings. 19. 3207-3211 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 波江野力他: 日本臨床. (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 宇根良衛他: 日本臨床. (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 波江野力他: 日本外科学会誌. (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Yoshida,M.C.et al: J.Hered.(1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Takeichi,N.et al: Gastroenterology.(1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 武市紀年他: 医学の歩み. 136. 379-380 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 武市紀年他: 北海道医学雑誌. 61. 471-472 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 伝法公麿他: 北海道医学雑誌. 61. 472 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 波江野力他: 免疫薬理. 5. 137-139 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 武市紀年他: メビオ. 4. 7 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 波江野力他: 病態生理. 6. 385-386 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Takeichi, N. et al.: "Combined innumodeficiency in LEC rats with spontaneous fulminant hepatitis." Igaku no ayumi (in japanese). 136. 379-380 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Takeichi, N. et al.: "Climinal and pathological studies of LEC rats with spontaneous fulminant hepatitis." Hokkaido J. Med. Sci. 61. 471-472 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Dempo, K. et al.: "Pathological study of LEC rats with spontaneous fulminant hepatitis." Hokkaido J. Med. Sci. 61. 472 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Namieno, T. et al.: "An animal model for hepatitis and hepatoma -- LEC rats --" Immunopharmacology and Therapy (in japanese). 5. 137-139 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Takeichi, N.: "Isolation of an inbied strain of LEC rats with spontaneous hepatitis and hepatoma. (FORUM)" Mebio. 4. 7 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Namieno, T. et al.: "Etiology for combined immunodeficiency in LEC rats with spontaneous hepatitis and hepatoma." Byotaiseiri (in japanese). 6. 385-386 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Matsumoto, K. et al.: "Expression of new esterases and pathologic profiles in LEC rats with spontaneous fulminant hepatitis." Transplantation Prpceedings. 19. 3207-3211 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Namieno, T. et al: "Hepatocholangio Disearas. 39. Experimental model for liver diseases. 6)Liver tumor." Nippon Rinsho. in press. (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Une, Y. et al.: "39. Experimental model for liver diseases. 5)Liver cirrhasis." Nippon Rinsho. in press. (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Namieo, T. et al.: "Establishment of LEC (Long Evans Cinnamon) rats with spontaneous hepatitis." Journal of Japan Surgical Society.in press. (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Yoshida, M.C. et al.: "New mutation causing hereditary hepatitis in the laboratory rats." J. Hered. in press. (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Takeichi, N. et al.: "Spontaneous hepatitis in Long-Exans rats: Apotential animal model for fulminant hepatitis in man." Gastroenterology. in press. (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Sasaki,M.et al.: Rat Nwws Letter. 14. 4-6 (1985)

    • Related Report
      1986 Annual Research Report
  • [Publications] 武市紀年、他: 医学のあゆみ. 133. 264-265 (1985)

    • Related Report
      1986 Annual Research Report
  • [Publications] 武市紀年、他: 医学のあゆみ. 136. 379-380 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 武市紀年、他: 北海道医学雑誌. 61. 471-472 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 波江野力、他: 免疫薬理. 5. 137-139 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Yoshida,M.C.et al: J.Hereditary. (1987)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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