Analysis of neuro oncogenesis by genetically different susceptible strains of rats.

• Project/Area Number: 61570175
• Research Category: Grant-in-Aid for General Scientific Research (C)
• Allocation Type: Single-year Grants
• Research Field: Experimental pathology
• Research Institution: HIROSHIMA UNIVERSITY
• Principal Investigator: ITO Akihiro Research Institute for Nuclear Medicine and Biology,Hiroshima Univ.,, 原爆放射能医学研究所, 教授 (60034633)
• Co-Investigator(Kenkyū-buntansha): NAITO Masashi Research Institute for Nuclear Medicine and Biology,Hiroshima Univ.,, 原爆放射能医学研究所・放射線誘発癌研究部門, 助手 (20127674) ; WATANABE Hiromitus Research Institute for Nuclear Medicine and Biology,Hiroshima Univ.,, 原爆放射能医学研究所・放射線誘発癌研究部門, 助教授 (00034653)
• Project Period (FY): 1986 – 1987
• Project Status: Completed (Fiscal Year 1987)
• Budget Amount: ¥2,200,000 (Direct Cost: ¥2,200,000); Fiscal Year 1987: ¥1,000,000 (Direct Cost: ¥1,000,000); Fiscal Year 1986: ¥1,200,000 (Direct Cost: ¥1,200,000)
• Keywords: 乳癌 / 腎腫瘍 / ラット / 系統差 / MNU / MNNG / 胃癌 / 肺腫瘍

Research Abstract

This study was primarily aimed to investigate the Ethyl-nitrosourea (ENU)induced neuro-oncogenesis in the different strains of rats.
By the administration of ENUinto newborn rats, almost 100% of brain cortical tumors, trigeminal nerve tumors could be induced.
Similar agents, methylnitrosourea (MNU) could also induce tumors at nervous systems, but also kidney and mammary tumors as well. Occurrence of kidney and mammary tumors has been unique, in which kidney tumor seemed to be regulated by recessive trait, but mammary tumors occur by the Mendel's law.
The study has been extended to analyze the genetical background in more details.

Research Products

• [Publications] 内藤正志: J.Natl.Cancer Inst.,. 74. 241-245 (1985)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] 内藤正志: Carcinogenesis. 8. 1807-1815 (1987)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] 内藤正志: Carcinogenesis. 9. (1988)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] 森雅弘: 日本毒性病理学会会誌. (1988)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Naito,M., Ito,A., Aoyama,H.: "Genetics of subceptibility of rats to trigemiral schwannomas induced by neonatal administration of N-ethyl-N-nitrosourea." J. Natl. Cancer Inst.,. 74. 241-245 (1985)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Naito, N., Naito, Y., and DiGiovanni, J.: "Comparison of the histological changes in the skin of DBA/2 and C57BL/6mice following expoure to various promoting agents." Carcinogenesis. 8. 1807-1815 (1987)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Naito, M., Chenicek, K.J., Naito, Y. and Digiovanni, J.: "Susceptibility to pherbol ester skin tumor promotion in (C57BL/6 x DBA/2)F_1 mice is inherited as an incomplete dominant trait; Evidence for multi-locus involvement." Carcinogenesis. 9. (1988)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Takahashi, T., Watanabe, H., Nakagawa, Y., Mori, M., Aoyama, H. and Ito, A.: "Tumorigenecity Study in B6C3F_1 mice by Califorinium-252_<1.2.3.>" J. Radiation Research.29. (1988)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] 伊藤明弘: Cancer Research. 45. 6436-6441 (1985)
• [Publications] 伊藤明弘: Pars Distalis of the Pituitary Gland Structure,Function.673. 491-495 (1986)
• [Publications] 伊藤明弘: Jornal of Radiation Research.27. 42 (1986)
• [Publications] 伊藤明弘: Jornal of the National Cancer Institute.77. 277-281 (1986)
• [Publications] 渡辺敦光: Gann.78. 27-31 (1987)
• [Publications] 内藤正志: Cancer Research. 46. 5836-5841 (1986)