| Project/Area Number |
61570175
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | HIROSHIMA UNIVERSITY |
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Principal Investigator |
ITO Akihiro Research Institute for Nuclear Medicine and Biology,Hiroshima Univ.,, 原爆放射能医学研究所, 教授 (60034633)
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| Co-Investigator(Kenkyū-buntansha) |
NAITO Masashi Research Institute for Nuclear Medicine and Biology,Hiroshima Univ.,, 原爆放射能医学研究所・放射線誘発癌研究部門, 助手 (20127674)
WATANABE Hiromitus Research Institute for Nuclear Medicine and Biology,Hiroshima Univ.,, 原爆放射能医学研究所・放射線誘発癌研究部門, 助教授 (00034653)
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| Project Period (FY) |
1986 – 1987
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| Project Status |
Completed (Fiscal Year 1987)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1987: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1986: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | 乳癌 / 腎腫瘍 / ラット / 系統差 / MNU / MNNG / 胃癌 / 肺腫瘍 |
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| Research Abstract |
This study was primarily aimed to investigate the Ethyl-nitrosourea (ENU)induced neuro-oncogenesis in the different strains of rats.
By the administration of ENUinto newborn rats, almost 100% of brain cortical tumors, trigeminal nerve tumors could be induced.
Similar agents, methylnitrosourea (MNU) could also induce tumors at nervous systems, but also kidney and mammary tumors as well. Occurrence of kidney and mammary tumors has been unique, in which kidney tumor seemed to be regulated by recessive trait, but mammary tumors occur by the Mendel's law.
The study has been extended to analyze the genetical background in more details.
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