Study on Threshold Limit Values of Occupational Allergens
| Project/Area Number |
61570261
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Kagoshima University |
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Principal Investigator |
UEDA Atsushi Kagoshima University Faculty of Medicine, Associate Professor, 医学部, 助教授 (10040198)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUSHITA Toshio Kagoshima University Faculty of Medicine, Professor, 医学部, 教授 (10022790)
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| Project Period (FY) |
1986 – 1987
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| Project Status |
Completed (Fiscal Year 1987)
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| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1987: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1986: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | Occupational allergen / Threshold Limit Values / Allergy / TDI / Chicken / Statice / Inhalation sensitizing experiment / ボデイプレチスモグラム / 感作性物質 |
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| Research Abstract |
First, we proved that there were only 8 countries which had the list or remark on occupational allergens and even in those countries no threshold limit values was set for preventing allergic diseases by an exposure to those allergens through personal communications and referring some reports. And we made a proposal of a new list of 80 substances for occupational allergens.
Next, we deviced an experimental system for a prediction and determination of it's dose-response relationship of occupational allergic substances, consisted of an equipment of generation and regulation of a test sample, exposure chamber, body-plethysmogramm, p-transducer, amplifier and recorder for respiratory rates, improving Karol's model, and proved it's appropriateness for that purpose by conducting an animal (guinea pigs) experiment of above mentioned using TDI as the test substance. It was also indicated that the grade of allergic reaction was depending on inhalative concentrations for sensitizing exposures and, nevertheless no respiratory immune reaction was observed by an exposure of 0.02 ppm TDI, skin immune reaction was observed at that concentration.
Third, we made it clear that a feather of chicken and flower of statice might cause human immediate allergic condition through conducting a field survey on allergy among workers handling those substances.
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Report
(2 results)
Research Products
(8 results)
