| Project/Area Number |
61570265
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Juntendo University |
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Principal Investigator |
INABA Yutaka Department of Hygiene, Juntendo University School of Medicine, 医学部, 助教授 (30010094)
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| Co-Investigator(Kenkyū-buntansha) |
市川 尚一 順天堂大学, 医学部, 助手
NAMIHISA Toshihiko Department of Gastroenterology, Juntendo University School of Medicine, 医学部, 教授 (10052929)
ICHIKAWA Shoichi Department of Gastroenterology, Juntendo University School of Medicine
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| Project Period (FY) |
1986 – 1987
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1987: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1986: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | Retrospective Cohort Study / Liver Cancer / Liver Cirrhosis / Chronic Hepatitis / Survival Rate / Proportional Hazard Model / Hospital Records / 比例ハザードモデル |
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| Research Abstract |
In order to caluculate the survival rate of chronic liver diseases and to elucidate the risk factors of liver cancer, 1,034 patients of the chronic liver diseases were followed up. All patients were confirmed histologically from 1973 to 1982 in juntendo University hospital. Suspended personal risk factors. such as alcohol intake, cigarrette smoking, HBV markers and so on were obtained from hospital records. Untill the end of 1986, all cases were mainly followed by koseki system. The mean follow-up period was 7.1 and 244 cases were died including 52 cases of liver cancer. The number of liver cancer death was 34(or 12.7%) of male liver cirrhosis, 5(or 5.0%) of female liver cirrhosis, 11(or,2.3%) of male chronic hepatitis and 1(or 0.6%) of temale chronic hepatitis, respectively.
The 10 years survival rate by Kaplan-Meyer's method ranged from 39.85 for male liver cirrhosis to 80.64 for male chronic hepatitis. The results of proportional hazard mofel for male liver cirrhosis revealed that drinking alcohol affected negatively to the liver cancer, and that cigarrette smoking and no history of operation due to portal hypertension affected to it and that age at biopsy HBS antigen, history of blood transfusion and history of acute hepatitis almost have no relation to it.
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