Correlation between gastric emptying time and plasma gastrointestinal hormone levels in experimentally induced diabetic dogs.
| Project/Area Number |
61570324
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | TOHOKU UNIVERSITY |
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Principal Investigator |
ISHIMORI Akira Tohoku University School of Medicine, Professor, 医学部, 教授 (60004793)
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| Co-Investigator(Kenkyū-buntansha) |
KOIZUMI Fumiaki Tohoku University School of Medicine,, 医学部, 助手 (90133058)
KAWAMURA Takeshi Tohoku University School of Medicine,, 医学部, 講師 (80111277)
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| Project Period (FY) |
1986 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1988: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1987: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1986: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | experimental diabetes / dogs / pancreatic polypeptide / insulin / glucagon / gastrin acetaminophen / グリカゴン |
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| Research Abstract |
Correlation between gastric emptying time and both plasma gastrin and pancreatic polypeptide (PP) levels after meal was studied in 9 normal and 5 streptozotocin (STZ) diabetic dogs. Moreover, the effects of exogenous insulin at doses of 0.2 and 0.4 U/kg on gastric emptying and plasma hormone levels were also studied in STZ diabetic dogs. The time required to reach the peak of plasma acetaminophen level, which is the indirect indicator of gastric emptying rate, was significantly delayed in STZ diabetic dogs than in control dogs. Plasma gatrin response was delayed slightly in STZ diabetic dogs, but the plasma levels were not significantly different between the two groups. Plasma PP levels both in the basal and after postprandial state were significantly higher in STZ dog than in normal dogs. Infusion of insulin did not affect plasma levels of acetaminophen and gastrin, while it produced a dose-dependent suppression of postprandial PP rise in STZ diabetic dogs. The foregoing data indicate that high level of plasma pp observed in STZ dogs did not correlate with gastric emptying but with insulin deficiency.
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Report
(4 results)
Research Products
(19 results)
