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Correlation between gastric emptying time and plasma gastrointestinal hormone levels in experimentally induced diabetic dogs.

Research Project

Project/Area Number 61570324
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionTOHOKU UNIVERSITY

Principal Investigator

ISHIMORI Akira  Tohoku University School of Medicine, Professor, 医学部, 教授 (60004793)

Co-Investigator(Kenkyū-buntansha) KOIZUMI Fumiaki  Tohoku University School of Medicine,, 医学部, 助手 (90133058)
KAWAMURA Takeshi  Tohoku University School of Medicine,, 医学部, 講師 (80111277)
Project Period (FY) 1986 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1988: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1987: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1986: ¥800,000 (Direct Cost: ¥800,000)
Keywordsexperimental diabetes / dogs / pancreatic polypeptide / insulin / glucagon / gastrin acetaminophen / グリカゴン
Research Abstract

Correlation between gastric emptying time and both plasma gastrin and pancreatic polypeptide (PP) levels after meal was studied in 9 normal and 5 streptozotocin (STZ) diabetic dogs. Moreover, the effects of exogenous insulin at doses of 0.2 and 0.4 U/kg on gastric emptying and plasma hormone levels were also studied in STZ diabetic dogs. The time required to reach the peak of plasma acetaminophen level, which is the indirect indicator of gastric emptying rate, was significantly delayed in STZ diabetic dogs than in control dogs. Plasma gatrin response was delayed slightly in STZ diabetic dogs, but the plasma levels were not significantly different between the two groups. Plasma PP levels both in the basal and after postprandial state were significantly higher in STZ dog than in normal dogs. Infusion of insulin did not affect plasma levels of acetaminophen and gastrin, while it produced a dose-dependent suppression of postprandial PP rise in STZ diabetic dogs. The foregoing data indicate that high level of plasma pp observed in STZ dogs did not correlate with gastric emptying but with insulin deficiency.

Report

(4 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report

Research Products

(19 results)

All Other

All Publications

  • [Publications] 小泉文明,川村武,石森章 他: 日本消化器病学会雑誌. 84. 2303-2306 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 小泉文明,川村武,石森章 他: 日本消化器病学会雑誌. 85. 2559-2562 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 小泉文明,川村武,石森章: 日本消化器病学会雑誌.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 石森章,小泉文明: 病態生理.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] F.Koizumi, et.al: Dia betolosia.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 石森章,小泉文明: "PPおよび関連消化管ホルモン 消化管ホルモン(vii)" 消化管ホルモン研究会, 10 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 小泉文明,山下由美,蝦名弘子,本田一陽,川村武,石森章,佐藤玄徳: "血中アセトアミノフェン濃度を指標とした胃排出能の検討 第3回研究会記録集" TDM治療研究会, 11 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Koizumi F et al: "Correlation between gastric emptying and the response of pancreatic polypeptide to test meals in peptic ulcer diseases." Tohoku J Exp Med. 151. 275-281 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Koizumi F et al: "Plasma paracetamol concentrations measured by fluorescence polarization immunoassay and gastric emptying time." Tohoku J Exp Med. 155. 159-164 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Koizumi F et al: "Correlation between gastric emptying time and both plasma gastrin and pancreatic polypeptide in streptozotocin diabetic dogs" Japanese J Gstroeneterology.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Fumiaki,Koizumi, et al: Tohoku J exp Med. 155. 159-164 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 小泉文明 他: "血中アセトアミノフェン濃度を指標とした胃排出能の検討第3回研究会記録集" TDM治療研究会, (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 小泉文明 他: "血中アセトアミノフェン濃度を指標とした胃排出能の検討第3回研究会記録集" TDM治療研究会, (1988)(English translation is not available.)

    • Related Report
      1988 Annual Research Report
  • [Publications] 小泉文明 他: 日本消化器病学会雑誌. 84. 2303-2306 (1987)

    • Related Report
      1987 Final Research Report Summary
  • [Publications] Fumiaki KOIZUMI et al: Tohoku J exp Med.

    • Related Report
      1987 Final Research Report Summary
  • [Publications] 石森章,小泉文明: "PPおよび関連消化管ホルモン,消化管ホルモン(Vii)" 消化管ホルモン研究会, 10 (1987)

    • Related Report
      1987 Final Research Report Summary
  • [Publications] 小泉文明 他: "丁中アセトアミノフェン濃度を指標とした胃俳出能の検討,第3回研究会記録集" TDM治療研究会, 11 (1988)

    • Related Report
      1987 Final Research Report Summary
  • [Publications] 小泉文明: 日本消化器病学会雑誌.

    • Related Report
      1986 Annual Research Report
  • [Publications] 石森章: "PPおよび関連消化管ホルモン、消化管ホルモン(投稿中)" 消化管ホルモン研究会, (1987)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-30   Modified: 2016-04-21  

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