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Encephalitogenic activity induced by immunization with cerebral endothelial cell membrane

Research Project

Project/Area Number 61570385
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Neurology
Research InstitutionShinshu University, School of Medicine

Principal Investigator

TSUKADA Yaoyuki  Department of Medicine, Shinshu University, School of Medicine, 医学部附属病院第3内科・文部教官, 講師 (90020792)

Co-Investigator(Kenkyū-buntansha) KOH Chang-Sung  Department of Medicine, Shinshu University, School of Medicine, 医学部附属病院第3内科・文部教官, 助手 (80143981)
Project Period (FY) 1986 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1987: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1986: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsCerebral endothelial cell / Cell membrane antigen / 脱髄
Research Abstract

Chronic experimental allergic encephalomyelitis induced by immunization with cerebral endothelial cell membrane bore a striking similarities to the brain in multiplw sclerosis. Two major bands, fraction I(9,OK) and II(12.3K), were obtained by polyacrylamide gel electrophoresis of cerebral endothelial cell membrane in sodium dodecyl sulfate. The mimbrane fractions were extracted from polyacrylamide gel and were purified by dialysis with distilled water. Each fraciton was screen for its ability as an agent in inducing demyelination in the immunized animals. Fraction I producd demyelination in 8 of the 10 immunized animals. This ma be a useful animal model for the investigation of the human demyelinating diseases.

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] N.Tsukada et al.: Journal of Neuroimmunology. 12. 89-97 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Y.Tanaka;N.Tsukada et al.: Journal of Neuroimmunology. 17. 49-59 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] N.Tsukada et al.: Acta Neuropathological(Berl). 73. 259-266 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Broman T. Et al.: "Blood-brain Barrier damage in multiple sclerosis. Supra-vital test observations." Acta Neurol Scand(suppl 10). 40. 21-24 (1964)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Brown WJ et al.: "The capillaries in acute and subacute multiple sclerosis plaques- a morphometric analysis." Neurology. 28. 84-92 (1978)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Tsukada N. et al.: "A new model for multiple sclerosis: chronic experimental allergic encephalomyelitis induced by immunization with cerebral endothelial cell membrane." Acta Neuropathologica(Berl). 73. 259-266 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Tsukada N. et al.: "Anti-endothelial cell antibody and immune complexes in the sera of animals with acute experimental allergic encephalomyelitis and chronic relapsing experimental allergic encephalomyelitis." Jouranl of Neuroimmunology. 12. 89-97 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] N.Tsukada et al.: J.Neuroimmunol.12. 89-97 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] N.Tsukada et al.: Acta Neropathol(Berl).

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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