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Research for retroviruses in thymus cells of myasthenia gravis and their involvement in the pathogeneses of myasthenia gravis

Research Project

Project/Area Number 61570394
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Neurology
Research InstitutionThe Kitassto Institute

Principal Investigator

ONO Kairo  Departmrnt of Virology,The Kitasato Institute, ウイルス部, 副部長 (80160901)

Co-Investigator(Kenkyū-buntansha) HIBI Toshifumi  Department of Internal Medicine,The Kitasato Institute Hospital, 病院内科, 医長 (50129623)
MORITA Minoru  Department of Virology,The Kitasato Institute, ウイルス部, 技師補
KOMATSU Haruko  Department of Virology,The Kitasato Institute, ウイルス部, 技師 (20106678)
Project Period (FY) 1986 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1987: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1986: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywordsmyasthenia graves / thymus / retrovirus / cDNA / ウイルス遺伝子のクローニング / HTLV / 逆転写酵素
Research Abstract

Retrovirus-like particles were demonstrated in cultured thymus cells(thymomas and thymus hyperplasias)of parients with myasthenia gravis.Human T cells were infected with these particles.Reverse transcriptase activity was eluted in the culture fluids of these T cells.Virus particles were also detected in these T cells.In Southern blot,cDNA prepared by endogenous polymerase reaction with detergent-treated virons from virus-infected T cells hybridized to DNAs of virus-infected T cells.Antibodies to such virus particles were detected in sera of parients with myasthenia gravis.Virus particles were also demonstrated in sv 40 DNA (ori^-)-transformed human thymus epithelial cell lines.

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Ono,A.: Neuroimmunological Disease-Recent Advance in Pathogenesis and Treatment-.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 小野明: Medical Immunology. 11. 445-452 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 小野明: 医学のあゆみ. 142. 701-703 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 小野明: 免疫性神経疾患に関する研究厚生省特定疾患免疫性神経疾患調査研究班. 475-480 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 小野明: Medical Way. 11. 10 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 土屋雅春: 日本胸部臨床. 46. 709-715 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 小野明: "胸腺腫ならびにその関連腫瘍-基礎と臨床-" 共和企画通信, 172 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Akira Ono: "Retrovirus in human thymus cells--with reference to the genesis of thymic desorders in myasthenia gravis -" Neuroimmunological Disease--Recent Advance in Pathogeneses and Treatment-. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Akiro Ono: "myasthenia gravis--virus and thymic changes-" Medical Immunology. 11. 445-452 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Akira Ono: "Viral eriology in ulcerative colitis and Crohn's disease" Igaku No Ayumi. 142. 701-703 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Akira Ono: "Research for retroviruses in thymus cells of myasthenia gravis" Research on Neuroimmunological Disease. 475-480 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Akira Ono: "Human thymus retrovirus" Medical Way. 11. 10 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Akiro Ono: Kyowa Kikaku Tsushin. Thymomas and their relevant tumors, 68-71 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 小野明: Medical Immunology. 11. 445-452 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 小野明: 免疫性神経疾患に関する研究(昭和60年度研究報告書)厚生省特定疾患免疫性神経疾患調査研究班. 475-480 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 小野明: Medical Way. 11. 10 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 土屋雅春: 最新医学. 41. 2525-2530 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 水野嘉夫: 免疫性神経疾患に関する研究(昭和60年度研究報告書)厚生省特定疾患免疫性神経疾患調査研究班. 264-268 (1986)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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