| Project/Area Number |
61570401
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | TOHOKU UNIVERSITY |
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Principal Investigator |
IMAI Yutaka Second Department of Medicine, Tohoku University, 第二内科, 助手 (40133946)
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| Co-Investigator(Kenkyū-buntansha) |
ABE. Keishi Department of clinical biology and hormonal regulation, 病態液性調節学講座, 教授 (60004777)
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| Project Period (FY) |
1986 – 1987
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| Project Status |
Completed (Fiscal Year 1987)
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| Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1987: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1986: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | Vasopiressin / Long-Evans rat / Brattleboro rat / Spontaneous hypertensive rat / Cerebrolateral ventricle / Depressor effect / 徐脈作用 / 中枢神経 / 孤束核 / 心血管反応 / 脳定位固定 / 降圧反応 / 昇圧反応 |
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| Research Abstract |
The cardiovascular effects of centrally administered arginine vasopressin were studied in stroke-prone spontaneously hypertensive rats and Wistar-Kyoto rats. Arginine vasopressin was infused intracerebroventricularly into conscious rats at a rate of 2 pg/kg/min (4.6 <micrn>/hr) for 21 hours, and blood pressure and heart rate were monitored. Agrinine vasopressin caused transient hypertension and tachycardia in Wistar-Kyoto rats, whereas it induced delayed hypotension and bradycardia in stroke-prone spontaneously hypertensive rats. The effects on the latter lasted for 24 to 72 hours after cessation of the infusion. Intravenous administration of arginine vasopressin at a rate of 2 pg/kg/min did not cause any change in blood pressure and heart rate in these rats. These results suggest that arginine vasopressin acts centrally to depress cardiovacular activites, at least in stroke-prone spontaneously hypertensive rats.
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