| Project/Area Number |
61570429
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
TAKEDA Nobuakira The Jikei University School of Medicine, 医学部, 講師 (60112835)
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| Project Period (FY) |
1986 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1988: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1987: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1986: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | SHR / Pressure overload / Volume overload / Papillary muscle / Tension / Isoproterenol / DBcAMP / ミオシンアイソザイム / 心肥大 / 自然発症高血圧ラット / 大動脈狭窄ラット / AVシャントラット / Hydroxyproline / DNA含量 / 降圧剤 / 圧負荷肥大心 / 容量負荷肥大心 / 発生張力 / 左室乳頭筋 / カテコラミン反応性 / dibutyryl cyclic AMP |
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| Research Abstract |
Alterations in myocardial contractility and biochemics were investigated in hypertensive, pressure-overloaded and volume-overloaded cardiac hypertrophy.Spontaneously hypertensive rats (SHR), abdominal aortic stenosis rats (AS rats) and aorto-caval shunt rats (AV shunt rats) were used. Isometric developed tension (T) of left ventricular papillary muscles from 30-week-old male SHR was not significantly different from that of age-matched Wistar Kyoto rats (WKY) and dT/dt showed a tendency to decrease in SHR. Myocardial mechanical responsiveness to isoproterenol and DBcAMP showed no difference between SHR and WKY. Left ventricular myosin isoenzyme pattern shifted to VM-3 in SHR. Both in chronic pressure- and volume-overloaded cardiac hypertrophy T was not significantly different from that of controls, but dT/dt was decreased in hypertrophied Myocardium. myocardium mechanical responsiveness to isoproterenol and DBcAMP was depressed in hypertrophied myocardium. Left ventricular myosin isoenzyme pattern was shifted to VM-3 in hypertrophied myocardium. Long term treatment of SHR with hydralazine and captopril reduced blood pressure in the same degree, but ventricular to body weight ratio decreased only in captopril-treated group. Left ventricular isoenzyme pattern shifted to VM-1 more distinctly in captopril-treated than in hydralazine-treated group.
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