| Project/Area Number |
61570434
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
鎌田 勲昭 医学部〓1内科学, 助手
KOKA Hironari Kinki University School of Medicine, 手 (50215208)
SHIMIZU Minoru Kinki University School of Medicine, 講師 (20178990)
小川 巌 医学部〓1内科学, 講師 (60204070)
ODA Akio Kinki University School of Medicine (20169303)
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| Project Period (FY) |
1986 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1988: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1987: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1986: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | Acute myocardial infarction / Coronary thrombolysis / Coronary stenosis / 心筋サルベージ / 冠動脈狭窄 / 心筋梗塞 / 冠再開通傷害 / 冠動脈 / 心筋浮腫 / 心筋 / 冠再灌流 / 心筋保護 / マンニトール / 心筋壁厚 |
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| Research Abstract |
The left anterior descending coronary artery in dogs was occluded of study the myocardial mechanics following reperfusion regarding 3 questions:
1) Time course change of wall thickness at the occluded area 2) Effects of mannitol to salvage the infarcted myocardium 3) Effects of residual coronary stenosis on the myocardial salvage. We found that after reperfusion, there is a biphasic increare in wall thickness, possibly related to reactive hyperemia and myocardial edema. Myocardial salvage was evident by Mannitol infusion at the outer wall of the infarcted area, possibly reflecting the free radical scavenging action of Mannitol. Residual stenosis of more than 99% coronary stenosis causes deleterious effects on myocardial salvage and thus we concluded the necessity of emergent PTCA. We could reach conclusions each on 3 items during this budget period.
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