| Project/Area Number |
61570457
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Division of Child Neurology, Tottori University School of Medicine |
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Principal Investigator |
ANDO Yukinori (1987) Associate, Dvision of Child Neurology,Tottori University, 医学部, 助手 (90168047)
高嶋 幸男 鳥取大学, 医学部, 助教授 (70038743)
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| Co-Investigator(Kenkyū-buntansha) |
MITO Takashi Associate, Division of Child Neurology, Tottori University, 医学部附属病院, 助手 (00166068)
TAKASHIMA Sachio Head, Division of Mental Retardation and Birth Defect Research, National Center, 神経センター, 部長 (70038743)
安藤 幸典 鳥取大学, 医学部, 助手 (90168047)
大野 耕策 鳥取大学, 医学部, 講師 (70112109)
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| Project Period (FY) |
1986 – 1987
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| Project Status |
Completed (Fiscal Year 1987)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1987: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1986: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | Neuron / Dendrite / Synapsis / Developmental delay / Dementia / 痴呆 / 脳発達 / ニユーロン / 脳低酸素症 |
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| Research Abstract |
This study was done by three methods of Golgi study, animal experiment and tissue culture. In Golgi study of human autopsied patients, neuronal dendrites in the cerebral cortex of infants with neonatal asphyxia or chronic lung diseases showed delayed maturation. The dendritic spines of neurons in the medullary reticular formation of sudden infant death syndrome showed incomplete development in comparison of controls. However, the neurons in the antrior and posterior horns of the cervical spinal cord maturated mormally. Thus, maturating neurons could be more influenced by environment and should be stimmulated during this period.
In animal experiment, young rabbits had hypoxic-ischemic insults and then necrotic lesions in the cerebral cortex. Golgi study of these subjects showed decreased dendritic length and spine density. However, the dendritic length and spine density could not be increased by motor exercise.
On the other hand, skin fibroblasts taken from infants and adults with Down's s syndrome (DS) were cultured and compared in several kinds of fetal serum (FCS) concentration. Fibroblasts from infants with DS showed slow proliferation curve in lower FCS concentration, which was corrected by higher concentration. But, fibroblasts from adults with DS were well proliferated only by artificial serum. These findings indicate cell characteristics of DS and may be related to mental retardation or precocious aging in DS.
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