| Project/Area Number |
61570488
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Shiga University of Medical Science |
|---|
Principal Investigator |
UEHARA Masami Department of Mermatology, Shiga Univerity of Medical Science, 医学部, 助教授 (70026871)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SUGIURA Hisashi Department of Dermatology, Shiga University of Medical Science, 医学部, 助手 (00162868)
|
|---|
| Project Period (FY) |
1986 – 1987
|
| Project Status |
Completed (Fiscal Year 1987)
|
| Budget Amount *help |
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1987: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1986: ¥1,600,000 (Direct Cost: ¥1,600,000)
|
|---|
| Keywords | Atopic dermatitis / DNCB dermatitis / Infiltrating lymphocyte subsets / Suppressor T cell / ランゲルハンス細胞 / 湿疹性病変 / 浸潤T細胞サブセット / サプレッサーT細胞 |
|---|
| Research Abstract |
Using a series of monoclonal antibodies, the tissue distributions of lymphocyte subpopulations and Langerhans cells were studied in frozen sections of 30 biopsy specimens from 1) acute, subacute and chronic skin lesions of atopic dermatitis, and 2) acute and chronic skin lesions of allergic contact dermatitis which were provoked in patients with atopic dermatitis.
In both acute and chronic skin lesions of atopic dermatitis, the infiltrating lymphocytes were composed entirely of T cells. Helper T cell/suppressor T cell ratio was remarkably high (10.9) in the acute lesions, while the ratio was only slightly elevated (3.5) in the chronic lesions. Thus, a very high helper T cell/ suppressor T cell ratio seems to be a characteristic feature of acute skin lesions of atopic dermatitis. However, suppressor T cells considerably increase in number as the skin lesions become more chronic.
In both acute and chronic skin lesions of allergic contact dermatitis which wer provoked in patients with atopic dermatitis, the infiltrating lymphocytes were composed of T cells. Helper T cell/suppressor T cell ratio was moderately elevated (4.2) in the acute lesions, while the ratio was not elevated (1.4) in the chronic lesions.
Thus, it became evident that the tissue distributions of suppressor T cells dynamically change through the evolution of skin lesions of atopic dermatitis. The pattern of evolutionary change of suppressor T cell distribution was very similar between atopic dermatitis and allergic contact dermatitis. Langerhans cells were consistently increased in the epidermis and dermis in all skin lesionsexamined.
|
