| Project/Area Number |
61570503
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Gunma University |
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Principal Investigator |
MITSUHASHI Norio Gunma University School of Medicine Assist.Prof., 医学部, 講師 (20008585)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAKAWA Michitaka Gunma University School of Medicine Instructor, 医学部, 助手 (40182414)
HAYAKAWA Kazuhige Gunma University School of Medicine Instructor, 医学部, 助手 (70114189)
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| Project Period (FY) |
1986 – 1987
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| Project Status |
Completed (Fiscal Year 1987)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1987: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1986: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | Tumor Immunity / Tumor marker / Monoclonal antibody / Nude mouse / Immunohistopathology / Tumor specific antigen / 放射線治療 |
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| Research Abstract |
1. Studies on immunological changes by iiradiation in tumor-bearing hosts
(1) Determinations of serum SCC antigen level
Positive rate of serum SCC level was 19% in patients with malignant tumors, 8% with various non-malignant diseases and 0% in healthy control. High serum levels of SCC were found in patients with esophageal cancer, cervical cancer, pulmonary cancer skin cancer and vaginal & vulval cancer. According to the histological types, differentiated squamous cell carcinoma appeard to produce a higher serum level of SCC antigen than other histological types. Elevated serum levels of SCC antigen rapidly decreased to a normal level after radio-therapy.
2. Studies on the optimal administration method of an immunopotentiator
(1) Clinical studies
PS-K was given orally 3.0g per day intermittently in the pattern of 2 weeks per month after radiation therapy. Intermittent administration of PS-K is effective and the period of withdrawal of the drug should be within 2 months when the patient is under good general condition.
(2) Experimental studies
The effects of PS-K on mice were studied histopathologically in lymphoid tissues in longest period and also when used with radiation. Distinctive changes which indicated the effects of PS-K were observed in reticuloendo-thelial system. Appearance of an obvious structureless-like translucentsub-stance followed the activation of the reticuloendothelial system.
3. Studies on evaluation of immunoscintigraphy using I-131 labeled anti CEA and anti CA 19-9 monoclonal antibody(IMACIS 1)
The positive scintigraphies were obtained in 66 of 86 cases(77%) clinically. There was significant correlation of positive ratio with tumor size.
The nude mice that were bearing human lung cancer were recieved administration of IMACIS 1. Then the positive scintigraphies were obtained.
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