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Research for splinctein mechanism of lower esophagus in children

Research Project

Project/Area Number 61570603
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionChiba University

Principal Investigator

TAKAHASHI Hideyo  Chiba Univ. Hospital Pediatvic Surgical department, Professor, 附属病院 小児外科, 教授 (00009474)

Co-Investigator(Kenkyū-buntansha) OHSUMA Naomi  Chiba Univ. Hospital Pediatvic Surgical department, 医学部 小児外科, 助手 (50125910)
MAIE Masahiko  Chiba Univ. Hospital Pediatvic Surgical department, 医学部 小児外科, 講師 (80009480)
Project Period (FY) 1986 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1988: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1987: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1986: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsChildren / Gastroesophageal reflux / esophageal manometry / 24 hour lower exphageal / pH momitoring / 食道胃接合部 / 食道内圧 / 食道内pH測定 / 自動計測 / フーリエ変換 / low compriance pump / コンピュータ
Research Abstract

The purpose of this study was to investigate the mechanisms of lower esophageal sphincter and its dysfunction in children by means of esophageal manometric study and 24 hour esophageal pH monitoring.
1.The method of esophageal pH monitoring for children was established,and monitoring system was computerized. The system composed of pH glass electrode,pH amplifier,A-D converter,and computer.The pH electrode was positioned 2cm above the lower esophageal sphincter,and pH data was collected for 24 hours(sampling interval,2sec.).All data were stored in computer,and analysed automatically after the examination was finished by comuter system.
2.GER,pyloric stenosis,hiatus hernia cases were studied by esophageal manometry and pH monitoring.Hiatal hernia case showed disturbance in manometric findings.In pyloric stenosis severe gastro esophageal reflux was existed,but esophageal clearance was maintained,and pH study findings recover only one week after surgical repair.In GER case pH monitoring was correlated with severity of the symptoms.
3.Radiological evaluation of gastro esophageal reflux was estimated statistically by quantification theory.Grade of reflux,patulous hiatus,delayed reflux had correlation with pH monitoring.
4.The histogram of pH data and reflux duration were edxamined.The pattern of the pH histogram was different when the cause of reflux was different.

Report

(4 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • 1986 Annual Research Report

Research Products

(15 results)

All Other

All Publications (15 results)

  • [Publications] 真家雅彦: 小児外科. 18. 483-490 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 岩井潤: 小児外科. 20. 283-292 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 岩井潤: 東京小児外科研究会の歩み. 2. 23-25 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 岩井潤: 外科診療. 30. 1764-1765 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Masahiko, Maie: "Gasfro esopbageal Reflux and Its Diagnostic Prodems" Jap. J. Pediatric Surg.18. 483-490 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Jun, Iwai: "Radiological evaluation of Gastroesophageal Reflux in Infants and Children : statistical analysis of Rakiological Studies by Quanfification Theory." Jap. J. Pediatric Surg.20. 283-292 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Jun, Iwai: "Conservative Therapy of Pediatric Gastro esophageal Reflux Cases." Abstracts of 62th Meeting of Tokyo Pediatric Sugeon Group. 2. 23-25 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Jun, Iwai: "Conservative Therapy of Pediatric GER cases" Geka Shinryo (Tokyo). 30(12). 1764-1765 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 岩井潤: 小児外科. 20(3). 283-292 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 岩井潤: 小児外科研究会の歩み. 2. 23-25 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 岩井潤: 外科診療. 30. 1764-1765 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 岩井潤,高橋英世,真家雅彦 他: 小児外科. 20. 283-292 (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] 真家雅彦,高橋英世,岩井潤: 小児外科. 18. 486-490 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 岩井潤,高橋英世,真家雅彦,大沼直躬,江東孝夫: 日本小児外科学会雑誌. 22. 322 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 真家雅彦,高橋英世,岩井潤: "基本小児外科学 日本小児外科学会教育委員会編 胃食道逆流現象" 金原出版, (1987)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-30   Modified: 2016-04-21  

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