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Study of alloantigen specific human suppressor T cell clone and its clinical application

Research Project

Project/Area Number 61570612
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionHIROSHIMA UNIVERSITY

Principal Investigator

FUKUDA Yasuhiko  Hiroshima Univ. School of Medicine. Associate Prof., 医学部, 講師 (40093801)

Co-Investigator(Kenkyū-buntansha) ASAHARA Tosimasa  Hiroshima Univ. School of Medicine. Assistant, 医学部, 助手 (70175850)
Project Period (FY) 1986 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1988: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1987: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1986: ¥900,000 (Direct Cost: ¥900,000)
KeywordsMixed lymphocyte culture / Human suppressor T cell clone / 非特異的免疫抑制因子 / 抑制性T細胞 / 同種抗原特異的抑制性T細胞 / 抑制性T細胞クローン / サプレッサーT細胞 / サプレッサーT細胞のクローニング
Research Abstract

We established 72 T cell clones generated from human one way MLC by recombinant IL-2 and feeder cells. Only one clone, -1-C5, had suppressor T cell like fuction, that is this clone showed ability to suppress the MLK but lacked cytotoxic property.
-1-C5 clone was not restricted by MHC(HLA-A,B,DR,DG). Its surface marker was CD3 and CD8 psitive.
The mechanism od suppression by this clone was due to soluble factor. The soluble factor was produced from this clone under the influence of gamma irradiated original MLR. Interestigly this factor showed non specific suppression. Like this soluble factor may be useful in the field of organ transplantation clinically in the future.

Report

(4 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • 1986 Annual Research Report
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] YAHATA H.;FUKUDA Y.;ASAHARA T.;ONO E.;DOHI K.: Japan J.Exp.Med.56. 257-264 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] YAHATA H.;FUKUDA Y.;TANAKA I.;ASAHARA T.;ONO E.;OMOTEHARA T.;DOHI K.: Transplantation Proceedings. 19. 540-543 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 八幡浩,福田康彦,浅原利正,石川哲大,土肥雪彦: 移植. 23. 138 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] YAHATA H.;FUKUDA Y.;ISHIKAWA T.;ASAHARA T.;DOHI K.: Transplantation Proceedings. (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] YAHATA H.; FUKUDA Y.; ASAHARA T.; ONO E.; DOHI K.: "Correlation between stable E-rosette formation and induction of alloantigen specific MLR suppressor cells in human mixed lymphocyte culture" Japan J. Exp. Med.56. 257-264 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] YAHATA H.; FUKUDA Y.; TANAKA I.; ASAHARA T.; ONO E.; OMOTEHARA T.; DOHI K.: "Establishment of an alloantigen-specific human suppressor T cell clone generated from one way mixed lymphocyte culture" Transplantation Proc.19. 540-543 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] YAHATA H.; FUKUDA Y.; ISHIKAWA T.; ASAHARA T.; DOHI K.: "Characterization of cloned human suppressor T cells generated from one way MLC" Transplantation Proc.in press. (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] YAHATA H.;FUKUDA Y.;TANAKA I.;ASAHARA T.;ONO T.;OMOTEHARA T.;DOHI K.: Transplantation Proceedings. 19. 540-543 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] 八幡浩、福田康彦、浅原利正、石川哲大、土肥雪彦: 移植. 23. 138 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] YAHATA H.;FUKUDA;Y.;JISHIKAWA T.;ASAHARA T.;DOHI K.: Transplantating Proceedings. 1989.

    • Related Report
      1988 Annual Research Report
  • [Publications] H. YAHATA: Transplantation Proceedings. 19. 540-543 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Hiroshi Yahata: Japan J.Exp.Med.56. 257-264 (1986)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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