Left ventricular contractility and diastolic property in severe burns

Research Project

Project/Area Number	61570627
Research Category	Grant-in-Aid for General Scientific Research (C)
Allocation Type	Single-year Grants
Research Field	General surgery
Research Institution	Kawasaki Medical School
Principal Investigator	SUZUKI Kouichiro Assist.Prof.,Emergency Medicine,Kawasaki Medical School, 救急医学, 助教授 (30122427)
Co-Investigator(Kenkyū-buntansha)	NISHINA Masayoshi 川崎医科大学, 救急医学, 講師 (20180622) OGASAWARA Yasuo Lecturer,Medical Engineering and Systems Cardiology,Kawasaki Medical School, システム循環器, 講師 (10152365) 辻岡克彦川崎医科大学, システム循環器, 助教授 (30163801) 梶谷文彦川崎医科大学, システム循環器, 教授 (70029114) KOHAMA Akitsugu 川崎医科大学, 救急医学, 教授 (30098610) TSUJIOKA Katsuhiko Assist.Prof.,Medical Engineering and Systems Cardiology,Kawasaki Medical school KAJIYA Fumihiko Prof.,Medical Engineering and systems Cardiology,Kawasaki Medical School 小田切徳正川崎医科大学, 救急医学, 助手 (90177238)
Project Period (FY)	1986 – 1987
Project Status	Completed (Fiscal Year 1987)
Budget Amount *help	¥2,200,000 (Direct Cost: ¥2,200,000) Fiscal Year 1987: ¥1,000,000 (Direct Cost: ¥1,000,000) Fiscal Year 1986: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywords	sever burn / left ventricular contractility / Emax / 左室収縮末期圧-容積関係 / Emax / 左室収縮末期圧-容量関係
Research Abstract	Left ventricular (LV) end-systolic pressure-volume relations (ESPVR) and end-diastolic pressure-valume relations (EDPVR) were studied in full-thickness and 50% body surface area burns in dogs.Sixteen mongrel (18-28kg) were divided into two groups; a sham-burn group (n=8) and a burn group (n=8).LV transmural pressure was measured using a high fidelity pressure transducer and LV volume was assessed in the anterior-posterior,septal-lateral,and apex-base demensions with three pairs of endocardial ultrasonic crystals.The ESPVR and the EDPVR were obtained during vena caval occlsions in each dog at control and 2h and 6h after burns.Other parameters of LV contractility (ejection fraction,peak dp/dt, mean Bcf and fractional shortening) were also examined at control and every 2h up to 6h after burns.There were no statistically significant differences in the slopes (Emax) of the ESPVR between the two groups.On the other hand,the 4 parameters of LV contractility were significantly depressed in the burn group as compared to those in the sham-burn group.Although the volume intercepts (v_0) of the ESPVR in the burn group tended to increase after burns,there were no ststistically significant differences in the post-burn changes in v_0 between the two groups.The severe burns had minimal effects on the EDPVR of the two groups.From these findings,we concluded that LV end-diastolic distensibility was not affected by the severe burns.Regarding the LV contractility after the severe burns,further studies may be necessary to resolve the reasons for discrepancies in the results for the Emax and the 4 parameters of contractility.