Bile Acid Metabolism after Total Colectomy
| Project/Area Number |
61570640
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
OKUBO Yasushi Tokyo Medical and Dental University : Assistant, 医学部, 助手 (00114786)
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| Co-Investigator(Kenkyū-buntansha) |
今城 真人 東京医科歯科大学, 医学部, 助手
IWAMA Takeo Tokyo Medical and Dental University : Assistant Professor, 医学部, 助教授 (70114741)
MISHIMA Yoshio Tokyo Medical and Dental University : Professor, 医学部, 教授 (00010158)
IMAJO Mahito Tokyo Medical and Dental University : Assistant
岩城 真人 東京医科歯科大学, 医学部, 助手
大久保 靖 東京医科歯科大学, 医学部・第2外科, 助手
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| Project Period (FY) |
1986 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1988: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1987: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1986: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | Faecal bile acid / Bile acid loading test / 終末回腸 / 大腸線腫症 / 大腸全摘術 / 血中胆汁酸分画 / 大腸腺腫症 / 胆汁酸代謝 |
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| Research Abstract |
Analysis of the faecal bile acids revealed that only 60cm ileum was important for the bile acid metabolism. In the feces from the ileostomy, the proportion of the primary bile acids increased markedly. The after the closure of the ileostomy, the components of the faecal bile acids were almost the same as the preoperative feces.
We injected 3 types of bile acids to the terminal ileum. Those were glycine-conjugated cholic acid (GCA), taurine-conjugated cholic acid (TCA) and ursodeoxycholic acid (UDCA). In the serum bile acids concentration analysis, UDCA traction increased most compared to the other two conjugated bile acids fraction. We also performed oral loading test of these 3 bile acids. It also revealed that UDCA indicated the highest serum response.
We conclude that the terminal ileum have the important role in the bile acid metabolism. But the degree of the absorption of the bile acids in the terminal ileum are different in each bile acid.
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Report
(4 results)
Research Products
(11 results)
