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Study of the regenerative capacity of the islet of Langerhans

Research Project

Project/Area Number 61570641
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionKanazawa University

Principal Investigator

YONEMURA Yutaka  Lecturer, Surgery II, School of Medicine, Kanazawa University, 医学部, 講師 (20167042)

Co-Investigator(Kenkyū-buntansha) 木村 寛伸  金沢大学, 医学部附属病院, 医員
小矢崎 直博  金沢大学, 医学部附属病院, 医員
西村 元一  金沢大学, 医学部附属病院, 医員
松田 裕一  金沢大学, 医学部附属病院, 医員
Project Period (FY) 1986 – 1988
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1988: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1987: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1986: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsParcreatectomy / diabetes mellitus / poly (ADP-ribose) synthetase inhibitor / regeneration of islet B cells / 膵B細胞の再生 / 膵切除 / ポリ(ADP-リボース)合成酵素阻害剤 / 膵再生 / 3-アミノベンズアミド
Research Abstract

1.3-Aminobenzamide as poly(ADP-ribose) synthetase inhibitor was given to 90% depancreatized rats. The regenerative activities of B cells were examined in attempt to clarify the mechanism of preventing surgical diabetes. On the 30th day after pancreatectiay, the islets treated with saline were reduced and the number of B cells decreased. In deparcreatized and 3-aminobenzomide treated rat (AB), the islets were enlarged and hyperplasia of B cells was seen. Autoradiography and stuthwokinetic studies showed labeling and mitotic indices of B cells in AB had a higher level than those of saline group. These results suggest that poly(ADP-ribose) synthetuse inhibitor can induce self-replication of B cells in partially depancreated rats.
2. While the onset of diabetic state was observed in 82% of depancreatized rats without 3-aminobenzaamide, 29% of 3-aminobenzamide treated rats fell into diabetic state the morphologic examination of remnant pancreas revealed the islets from 3-AB-treated rats were enlarged. The percentage of labelled B cells reached a peak in the rats killed 3 and 5 days after operation, and then declined gradually, the results indicate that 3-AB may prevent diabetes mellitas in partially depancreatized rats by maintaining the function of B cells.

Report

(4 results)
  • 1989 Final Research Report Summary
  • 1988 Annual Research Report
  • 1987 Annual Research Report
  • 1986 Annual Research Report
  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Terasono Kimio;Hiroshi Yamamoto;Shin Takasawa;Kiyoto Shiga;Yutaka Yonemura;Yoshihiro Tochino;Hiroshi Okamoto: The Journal of Biological Chemistry. 263. 2111-2114 (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] Yutaka Yonemura;Toru Takashima;Yuichi Matsuda;Koichi Miwa;Kazuo Sugiyama;Itsuo Miyazaki;Hiroshi Yamamoto;Hiroshi Okamoto: International Journal of pancreatology. 3. 702-703 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 米村豊, 松田祐一, 高嶋達, 杉山和夫, 宮崎逸夫, 山本博, 岡本宏: 現代医学. 20. 297-302 (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] Hiroshi Okamoto;Hiroshi Yamamoto;Yutaka Yonemura: ADP-ribosylation of proteins,Springer-Verlag,Berlin,New York,Tokyo.410-416 (1985)

    • Related Report
      1986 Annual Research Report
  • [Publications] Yutaka Yonemura;Toru Takashima;Koichi Miwa,et al: Diabetes. 33. 401-404 (1984)

    • Related Report
      1986 Annual Research Report
  • [Publications] 高嶋達: 膵臓. 1. 93-103 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 米村豊,宮崎逸夫,高嶋達,松木伸夫,荻野茂,沢敏治,高島茂樹,三輪晃一: 日本外科学会誌. 85. 356-362 (1984)

    • Related Report
      1986 Annual Research Report
  • [Publications] 米村豊,橋本哲夫,高嶋達,松田祐一,宮崎逸夫: 日本消化器外科学会誌. 19. 836-839 (1986)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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