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Radioimmunodetection of carcinoma of the stomach and colorectum by monoclonal antibodies

Research Project

Project/Area Number 61570645
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionNagoya University

Principal Investigator

WATANABE Tadashi  Nagoya University School of Medcine, Associate Professor, 医学部, 助教授 (20144157)

Co-Investigator(Kenkyū-buntansha) TAKAGI Hiroshi  Nagoya University School of Medicine, Professor, 医学部, 教授 (70154755)
Project Period (FY) 1986 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1988: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1987: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1986: ¥800,000 (Direct Cost: ¥800,000)
KeywordsColorectal Cancer / Monoclonal Antibody / Carcinoembryonic Antigen / 画像診断 / CEA / 直腸癌局所再発 / F(ab′)_2フラグメント / 癌胎児抗原 / 転移
Research Abstract

Radioimmunodetection using monoclonal antibody to tumor-associated antigen has the potential for the differential deagnosis between malignant and benign tissues. We produced the monoclonal antibodies, GC302 to gastric cancer, and CEA102 to colorectal cancer in our laboratory. The antigen recognized by GC302 is 40K and characterized as an oncofetal antigen in stomach,and also as a differentiation antigen whose localization discriminates between the gastrointestinal tracts of the forgut origin and midgut origin. CEA102 reacted with normal epitherium of fetal colon and almost all cancer of the colorectum. Other cancers or normal tissues such as melanoma, leukemic cells, and fibrous tissues were negative. Therefore GC302and CEA102 are good tool to detect metatatic sites of gastric and colorectal cancer, respectively.
After radioimmunoscintigraphy using xenografts could be done successfully, we applied this method to detect metastatic sites of patients with colorectal cancer. Six patients were studied with ^<131>I labeled CEA102, and two showed significant accunulation of antibody by scintigraphy. Moreover, we investigate to compare the excretion of antibody, and its accumulation to tumor between F(ab')_2 and whole CEA102. The results showed F(ab')_2 is better in excretion and accumulation of antibody. Therefore F(ab')_2 allows us to use^<123>I and Emission CT.

Report

(4 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • 1986 Annual Research Report
  • Research Products

    (33 results)

All Other

All Publications (33 results)

  • [Publications] 村山浩基: 日本外科学会雑誌. 90. (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] J.Sakamoto: Cancer Res.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] T.Ichihara: Cancer. 61. 324-333 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] S.Akiyama: Jpn.J.Surg.18. 438-446 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] T.Watanabe: Jpn.J.Surg.17. 506-516 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] I.Yokoyama: Jpn.J.Cancer Res.77. 1114-1121 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Hiroki Murayama: "Radioimmunodetection of colorectal cancer using anti-CEA monoclonal antibody" Geka Gakkai Zasshi. 90. (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] S. Sakamoto: "Expression of Lewis a, Lewis b, Lewis x, Lewis y, Sialyl-Lewis a and Sialyl-Lewis x blood group antigens in human gastric carcinoma and in normal gastric tissues" Cancer Res. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] S. Akiyama: "Characteristics of three gastric cancer cell lines NUGC 2,3,and 4" Jpn. J. Surg.18(40). 428-446 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] T Ichihara: "Immunohitochemical localization of CA19-9, and CEA in pancreatic carcinoma and associated disease" Cancer. 61. 324-333 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] T. Watanabe: "A stomach oncofetal antigen recognized by monoclonal antibody GC302" Jpn. J. Surg.17. 506-516 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 村山浩基: 日本外科学会雑誌. 90. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] J.Sakamoto: Cancer Res.(1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] T.Ichihara: J.Surgcal Onology. 40 (8). (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 坂本純一: がん治療のあゆみ. 7. 61-70 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] S.Akiyama: Jpn.J.Surg.18 (40). 428-446 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] T.Ichihara: Cancer. 61. 324-333 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] T. Watanabe: Jpn. J. Surgery. 17. 506-516 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] S. Akiyama;T. Watanabe: Jpn. J. Surgery. (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] T. Ichihara;T. Watanabe: Cancer. (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] T. Ichihara;T. Watanabe: J. Surgical Oncology. (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] H. Ichihashi;T. Watanabe: Excerpta Medica. 128-136 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 徳丸隆彦, 渡辺正: 日本消化器病学会雑誌. 84. 2494-2503 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 渡辺正: "手術:「直腸癌に対する骨盤内臓器全摘術」" 金原出版, 7 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 高木弘, 渡辺正: "新外科学体系"再発癌とその治療"" 中山書店,

    • Related Report
      1987 Annual Research Report
  • [Publications] I.Yokoyama.: Jpn.J.Cancer Res.(Gann). 77. 1114-1121 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] T.Watanabe: Jpn.J Surgery. (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] S.Akiyama: Jpn.J.Surgery. (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] 市原透: 消化器と免疫. 16. 268-272 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 浅岡峰雄: 肺癌.

    • Related Report
      1986 Annual Research Report
  • [Publications] 徳丸隆彦: 日本消化器病学会雑誌.

    • Related Report
      1986 Annual Research Report
  • [Publications] 高木弘: "The Latest Therapy シリーズ 「直腸癌局所再発の手術」" 医学教育出版社, 11 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 渡辺正: "手術 「直腸癌に対する骨盤内臓器全摘出術とその適応」" 金原出版, 7 (1987)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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