Mechanism of bile secretion under cholestatic condition (Metabolism and therapeutic efficacy of cholagogue)

Research Project

Project/Area Number	61570654
Research Category	Grant-in-Aid for General Scientific Research (C)
Allocation Type	Single-year Grants
Research Field	Digestive surgery
Research Institution	Kyushu University
Principal Investigator	ICHIMIYA Hitoshi (1987) Kyushu Univ. Fac. of Med. Assistant, 医学部, 助手 (10183170) 一宮仁 (1986) 九大, 医学部, 助手 (70184009)
Co-Investigator(Kenkyū-buntansha)	山内昌一郎九州大学, 医学部, 助手 (90158064)
Project Period (FY)	1986 – 1987
Project Status	Completed (Fiscal Year 1987)
Budget Amount *help	¥1,800,000 (Direct Cost: ¥1,800,000) Fiscal Year 1987: ¥200,000 (Direct Cost: ¥200,000) Fiscal Year 1986: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywords	Obstructive juandice / Bile acids / Bile secretion / Bile lipids / Cholagogue / 代謝及び変換 / 胆汁うっ滞
Research Abstract	Patients with obstructive jaundice are at significant risk of multiple organ failure following surgery, so that they are usually treated with biliary diversion to reduce their elevated serum bilirubin level. Secondary operations are performed after they restore hepatic functions. Howe er, there is a few preoperative estimations that reflect their conditions accurately. Bile salts which are synthesized from cholesterol in the hepatocyte and excreted into bile play a very important role during their enterohepatic circulations such as digestion, absorption and bile formation. The understanding of the dynamic aspects of the bile salts untabolsim has progressed rapidly int he past few years because of great advance in methodology. This investigation is framed to (1) clarify the effect of the administraion of cholagogue on the bile formation and to (2) evaluate the hepatic reduction capacity by means of monitoring the reduced (biotransformed) products in the course of recovery from cholestatic liver dysfunction.