| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1987: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1986: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Research Abstract |
The object of this study was to determine the critical flow rate (BFR) of the portosystemic bypass, using heparin coated catheter Anthrone, during acute portal vein occlusion (PVO). BFR was controlled at 10% (Group 1) , 30% (Group 2), 50% (Group 3) of the portal flow in the individual experimental groups of anesthetized dogs. Hemodynamic and biochemical changes were observed during 2 hours in each group.
With decreased BFR, portal venous pressure (P_<pv>) increased, with 47.1 mmHg in Group 1 and 26.8 mmHg in Group 2, and superior mesenteric arterial flow (F_<sma>) decreased remarkably in both Group 1 and Group 2. However, P_<sma> showed negligible changes in Group 3. Thus, negative correlation between BFR and P_<pv> (r=-0.911, P<0.0001), and positive correlation between BFR and F_<sma> (r=0.875, P<0.0001) were found respectively. With decreased BFR, portal venous blood hematocrit increased, with 54.5% in Group 1 and 50.3% in Group 2. Following 2 hours PVO, pH levels of portal venous blood were reduced, with 7.210 in Group 1 and 7.337 in Group 2. CPK-BB levels of portal venous blood correlated well to the degree of intestinal insultation.
In conclusions, the critical BFR must be between 10% and 30% of portal flow for life sustaining up to 2 hours PVO, and 50% BFR is sufficient enough in more than 2 hours PVO, in the aspect of mesenteric organ insultation.
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