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Effect of nonsteroidal androgen receptor antagonist on N-Amyl-N-methylnitrosamine(AMN) induced esophageal cancer in rats.

Research Project

Project/Area Number 61570660
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionTokai unversity

Principal Investigator

YASUMASA Kondoh  Instructor, 医学部, 助手 (00130063)

Co-Investigator(Kenkyū-buntansha) KYOJI Ogoshi  Assistant Professor, 医学部, 講師 (30112775)
HIROYASU Makuuchi  Assistant Proffesor, 医学部, 講師 (80095645)
Project Period (FY) 1986 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1987: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1986: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsEsophageal cancer / Antiandrogan / N-Amyl-N-methylnitrosamine / Experimental esophageal cancer / 実験食道癌 / 男性ホルモン受容体蛋白 / N-Amyl-N-methylnintrosanine
Research Abstract

The inhibitory effects of flutamide(SCH 13521 Schering Corporation), nonsteroida androgen receptor antagonist, on the retes of occurrence of esophageal cancer induced by AMN using by experimental system in rats were studied. The experimental system used was that of rat esophageal cancer induced by AMN dissolved in dringking water at a concentration of 0.003%. Flutamide was administrated as mixed into the diet in daily dose of 20mg. Male and female 6-week-old rats of Sorague-Dawlew(SD) strain were used, and castration was performed at 5 weeks of age. The animals were sacrificed from the 8th week to the 18th week at two weeks intervals after administration of AMN and the esophageal tissues were prepared to examine the esophageal cancer in pathological study. Statistical analysis was carried out using the generalized wilcoxon test. Values of p<0.05 were considered to be significant. The rates of occurrence of esophageal cancer of the castrated male rats with flutamide were lower those of the control male rats (p<0.01), those of the male rats with flutamide were lower than those of the cotrol male rats(p<0.05), those of the demale with flutamide and the castrated female rats with fultamide were lower that those of the casteated female rats(p<0.01), and those of the control female rats were lower than those of the castrated female rats(p<0.05). From these findings we specurate that flutamide has a inhibitory effect on the rates of occueence of esophageal cancer induced by AMN in rats.

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] 近藤泰理,生越喬二,幕内博康,三富利夫: 日本癌学会総会記事. 45. 76 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 近藤泰理,生越喬二,幕内博康,三富利夫: 日本外科学会雑誌. 181 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Y.KONDOH;K.OGOSHI and T.MITOMI: Proceedings of the 15th International Congress of Chemotherapy.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 近藤泰理,生越喬二,幕内博康,三富利夫: 日本癌治療学会誌. 22(8). 1826 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Yasumasa Kondoh, Kyoji Goshi, Hiroyasu Makuuchi, Toshio Mitomi: "Proceeding of the Japanese Cancer Association, 45th Annual Meeting" Effect of nonsteroidal androgen receptor antagonist on N-Amyl-N-methyinitrosamine(AMN) induced esophageal cancer in rats.45. 76 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Yasumasa Kondoh, Kyoji Ogoshi, Hitoyasu Makuuchi, Toshio Mitomi: "Proceeding og the Japan Surgical Society, 87th Annual Meeting" Effect or nonsteroidal antiandrogen on AMN induced esophageal cancer in rats.87. 181 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Yasumasa Kondoh, Kyoji Ogoshi and Toshio Mitomi: "Effect of nonsteroidal androgen receptor antagonist on N-AmylN-methylnitrosamine-induced esophageal cancer in rats." Proceeding or the 15th International Congress of Chemotherapy.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Yasamasa Kondoh, Kyoji Ogoshi, Hiroyasu Makuuchi, Toshio Mitomi: "Antitumor effects of flutamide (antiandrogen drug) on AMN-induced esophageal cancer in rats." The Journal of Japan Society for Cancer Therapy. 22. 1826 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 近藤泰理: 日本癌学会総会記事. 第45回. 76-76 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 近藤泰理: 日本外科学会雑誌. 臨時増刊. 181-181 (1987)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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