| Project/Area Number |
61570660
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Tokai unversity |
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Principal Investigator |
YASUMASA Kondoh Instructor, 医学部, 助手 (00130063)
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| Co-Investigator(Kenkyū-buntansha) |
KYOJI Ogoshi Assistant Professor, 医学部, 講師 (30112775)
HIROYASU Makuuchi Assistant Proffesor, 医学部, 講師 (80095645)
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| Project Period (FY) |
1986 – 1987
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| Project Status |
Completed (Fiscal Year 1987)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1987: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1986: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | Esophageal cancer / Antiandrogan / N-Amyl-N-methylnitrosamine / Experimental esophageal cancer / 実験食道癌 / 男性ホルモン受容体蛋白 / N-Amyl-N-methylnintrosanine |
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| Research Abstract |
The inhibitory effects of flutamide(SCH 13521 Schering Corporation), nonsteroida androgen receptor antagonist, on the retes of occurrence of esophageal cancer induced by AMN using by experimental system in rats were studied. The experimental system used was that of rat esophageal cancer induced by AMN dissolved in dringking water at a concentration of 0.003%. Flutamide was administrated as mixed into the diet in daily dose of 20mg. Male and female 6-week-old rats of Sorague-Dawlew(SD) strain were used, and castration was performed at 5 weeks of age. The animals were sacrificed from the 8th week to the 18th week at two weeks intervals after administration of AMN and the esophageal tissues were prepared to examine the esophageal cancer in pathological study. Statistical analysis was carried out using the generalized wilcoxon test. Values of p<0.05 were considered to be significant. The rates of occurrence of esophageal cancer of the castrated male rats with flutamide were lower those of the control male rats (p<0.01), those of the male rats with flutamide were lower than those of the cotrol male rats(p<0.05), those of the demale with flutamide and the castrated female rats with fultamide were lower that those of the casteated female rats(p<0.01), and those of the control female rats were lower than those of the castrated female rats(p<0.05). From these findings we specurate that flutamide has a inhibitory effect on the rates of occueence of esophageal cancer induced by AMN in rats.
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