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Respiratory assist system with extracorporcal CO_2 removal for severe respiratory failure

Research Project

Project/Area Number 61570670
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionOsaka University

Principal Investigator

OHTANI Masakatsu  大阪大学, 医学部第一外科, 助手 (90168980)

Co-Investigator(Kenkyū-buntansha) 大久保 修和  大阪大学, 医学部附属病院, 医員
MATSUDA Hikaru  大阪大学, 医学部第一外科, 講師 (00028614)
OHKUBO Nobukazu  First Department of Surgery, Osaka University Hospital
Project Period (FY) 1986 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1987: ¥100,000 (Direct Cost: ¥100,000)
Fiscal Year 1986: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsRESPIRATORY FAILURE / EXTRACORPOREAL MEMBRANE OXYGENEATION / PULMONARY LEUKOCYTE SEQUESTRATION / 肺leukocyte sequestration / 機械的呼吸補助 / 膜型人工肺 / 白血球 / 補体
Research Abstract

ECCO_2Rにおける白血球活性化
体外循環においては異物と血液の接触により補体白血球系が活性化され, 活性化白血球は肺血管床にsequestrationを生じ組織障害をきたすことが指摘されている. ECCO_2Rにおいても同様の問題が考えられるので, 実験的ECCO_2Rにおいて肺leukosequestrationを中心に白血球動態を検討した. 更に白血球活性化を抑制するcAMP phosphodiesterase inhibitor(DN-9693)が白血球動態に与える影響を検討した. ECCO_2R早期に肺leukocyte sequestrationが生じ有意な白血球減少をきたした. 30分のECCO_2Rによって白血球数は約50%に減少した. DN-9693投与下のECCO_2Rでは肺leukosequestrationと白血球減少は認められず, DNー9693は肺血管床に対する白血球の作用を抑制する可能性が示された.
(第88回日本外科学会総会発表予定)

Report

(3 results)
  • 1988 Annual Research Report
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (5 results)

All Other

All Publications (5 results)

  • [Publications] 大谷正勝: Trans.Am.Soc.Artif.Intern.Organ.

    • Related Report
      1988 Annual Research Report
  • [Publications] 大谷正勝: Trans.Am Soc.Artif.Intern.Organ. 10. 453-455 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 大谷正勝: Trans.Am.Soc.Artif.Intern.Organ.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Masakatsu Ohtani et al: "Modification of an ECCO_2R system to improve CO_2 removal at very low blood flow rates." Trans American Society of Artificial Internal Organs. 10. 453-455 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Masakatsu Ohtani et al: "Attenuation of pulmonary leukocyte sequestration during extracorporeal circulation by a new phosphodiesterase inhibitor." Trans American Society of Artificial Internal Organs.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary

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Published: 1987-03-31   Modified: 2016-04-21  

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