Project/Area Number |
61570690
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Research Category |
Grant-in-Aid for General Scientific Research (C)
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Allocation Type | Single-year Grants |
Research Field |
Cerebral neurosurgery
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
MATSUTAIRA Tsuyumu Assistant Professor, Department of Neurosurgery, Tokyo Medical and Dental University, 医学部, 講師 (50014345)
|
Co-Investigator(Kenkyū-buntansha) |
清田 満 東京医科歯科大学, 医学部, 助手
鬼頭 清裕 東京医科歯科大学, 医学部, 助手 (30177878)
TONE Osamu Division of Neurosurgery, Musashino Red Cross Hospital, 医学部, 助手 (70188762)
青柳 昌樹 東京医科歯科大学, 医学部, 助手 (60175750)
MASAOKA Hiroyuki Assistant, Department of Neurosurgery, Tokyo Medical and Dental University
YAMAZAKI Shingo Division of Neurosurgery, Tsuchiura Kyodo Hospital
KUROIWA Toshihiko Division of Pathology, Malicious Disease (30178115)
田畑 均 東京医科歯科大学, 医学部脳神経外科, 助手 (80138479)
|
Project Period (FY) |
1986 – 1988
|
Project Status |
Completed (Fiscal Year 1988)
|
Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1988: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1987: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1986: ¥200,000 (Direct Cost: ¥200,000)
|
Keywords | CO2 laser / YAG laser / Coaxial laser exposure / Brain edema / Cerebral blood blow / Neurosurgical operation / 脳浮腫 / CO_2レーザー / 血管の照射 / Nd / YAGレーザー / 同軸同時多種レーザー照射 / 脳外科手術機械 / 脳血管 / マイクロアンギオグラフィー / Nα / マイクロアンジオグラフィー |
Research Abstract |
Chronic effects on the microvasculature of the rabbit brain were examined following one second exposure of Nd:YAG, CO2, and the combination of both lasers, using soft X-ray microangiography and HE staining. Nd:YAG laser exposure showed that the edematous layer with tapered vessels was enlarged and the number of vessels in edematous layer was not so enlarged as Nd:YAG laser and the structure of vessels was well preserved. Combined exposure resulted similar effects on vasculature as Nd:YAG laser preserving cutting effect in the chronic phase. The enlargement of edematous and oligovascular layer 2 days after Nd:YAG laser exposure should be considered in clinical application of nd:yag laser. To examine the cerebral blood flow changes by laser exposure, we have measured them at the adjacent site using laser Dopplar flow meter. For the control, bipolar coagulator was applied on the cerebral cortex for 1 second. A probe of laser Doppler flow meter was placed on the brain surface and regional cerebral blood flow, blood velosity and blood volume were recorded. At the site 2 mm distant from the exposure area, some increase of cerebral blood flow and blood velosity was observed. It continued about 2 to 5 minutes and returned to the control value. At the site more than 10 mm distant, slight or no detectable changes were observed. Moreover, coagulation by a bipolar coagulator brought about similar effects. From these results, it is concluded that the disturbance in the epicerebral microcirculation after laser exposure was localized, temporary and not specific for laser exposure.
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