| Project/Area Number |
61570726
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Saitama Medical University |
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Principal Investigator |
TSUZUKI Nobuyuki Department of Orthopaedic Surgery, Saitama Medical Center Saitama Medical School, 医学部, 教授 (10049794)
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| Project Period (FY) |
1986 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1988: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1987: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1986: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | Cervical spinal cord / Anterior horn cell / Cell diameter / Aging process / 圧迫性脊髄症 / 頸髄前角細胞直径 / 核小体直径 / histogram / 頚髄前角細胞直径 |
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| Research Abstract |
The aging pattern of the histogram of motor cells in the rexed IX zone(lateral portion) of C7 segment of human cervical cords was investigated by mesuring the diameter of the nucleolus. There existed a linear relationship between the diameter of the cell body and the nucleolus of the motor cell with the correlation coefficient 0.99-0.98.
We mesuared 30 cases for the aging analysis. These patients showed no neurological deficit when alive. General patterns were as follows: the histogram pattern of the nucleolus below ten years showed one peak-pattern with the peak value of 4 mu, while histograms between 2nd and 6th decades showed 2 peak-pattern with the peak values of 3.5 mu and 5mu respectively and histogrms after 7th decade showed one peak-pattern with the peak value of 5 mu. A compressed cervical cord of 55 years old female showed a tendency of the decrease of large cells compared to the aging pattern of the same age. These facts suggested the presence of the specific histogram pattern according to the environmental conditions of motor cells.
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