| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1987: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1986: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Research Abstract |
In order to assess the effects of spinally administered agents on spinal cord blood flow (SCBF), lumbal SCBF and cerebral blood flow(CBF) were measured simultaneously by the hydrogen clearance methods in dogs. The subarachinoid tetracaine, 5mg of lml, produced any significant changes in both SCBF and CBF,although arterial blood pressure decreased significantly after the administration. after subarachinoid eqinephrine, 1008300 and 500 ug/ml, SCBF varied widely but did not change significantly with any of the injections, nor did CBF.
Neihter butorphanol nor PGI_2 analog(OP-41483) affected SCBF when they administered subarachinoidally, though intravenous administration of the latter caused significant changes in SCBF and CBF as well as cerebrospinal fluid pressure. The subarachnoid clonidine produced significant decrease in SCBF.
Although our knowledge regarding SCBF effects of spinally administered agents is still insufficient, several investigators,Crosby in U.S.A., Kozody in Canada, Gordh in Sweeden, also reported the results of their similar studies which agree or disagree our present results.
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