| Project/Area Number |
61570742
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
麻酔学
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| Research Institution | Hiroshima University |
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Principal Investigator |
OSAFUMI YUGE Associate Professor, Department of Anesthesiology, Hiroshima University, School of Medicine, 医学部麻酔学教室, 助教授 (40034128)
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| Co-Investigator(Kenkyū-buntansha) |
MICHI MORIO Professor and Chairman, Department of Anesthesiology, Hiroshima University, Scho, 医学部麻酔学教室, 教授 (80033950)
KEIKO MUKAIDA Instructor, Department of Anesthesiology, Hiroshima University, School of Medici, 医学部附属病院麻酔科, 助手 (20182066)
石原 晋 広島大学, 医学部附属病院, 講師 (00106808)
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| Project Period (FY) |
1986 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1988: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1987: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1986: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | Surgical patients / Polymorphonuclear Leuckocytes(PMNLs) / Nitroblue Tetrazolium(NBT)還元反応 / 手術疾患 / 多核白血球貧食殺菌能 / ritroblve Tetrazolivm(NBT)還元反応 / 好中球貧食殺菌能 / NBT還元反応 / Nitroblve tetrazolium還元反応 / 好中球貪食殺菌能 / 感染防禦機能 |
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| Research Abstract |
This project was umdertaken to determine the background factors of surgical patients showing depression in phagocytic and bacteriocidal activity of meutrophils. In the patients with metabolic disorders (liver cirrhosis, hypoproteinemia and disbetes mellitus), especially in the aged patients more than 70 yrs old, phagovytic and bacteriocidal activity of neutrophils were observed by nitroblue tetrazolium (NBT) reduction test before and after general anesthesia for surgery.
Background factors other than the methods of anesthesia and surgical invasion were examined in the 32 patients who had values of less than 25% of the mean value for healthy adults both before and after anesthesia and surgery. The highest incidence of these low values was seen in malignant tumors, followed by anamia, diabetes mellitus and hypoproteinemia, longterm administration of steroids, renal insufficiency and complications of liver cirrhosis, use of immunosuppressants. obesity and in subjects aged over 70 years.
However, the percentages of low values in the background factors among all the 108 cases were 100% for renal insufficiency and liver cirrhosis, 90% for hypoproteinemia, 80% each for diabetes mellitus, longterm administration of steriods and immunosuppressants, 60% each for obesity and anemia, and only 32% malignant tumors. When compaired with the mormal surgical patiemts group (N=15), phagocytic and bacteriocidal function was suppressed in the patients group with metabolic disorders and aged patients group.
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