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Metesudar Bfodooical Analysis of Metastatic Factor in Human Gestational Choriocarcinomas

Research Project

Project/Area Number 61570785
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionNiigata University

Principal Investigator

TAKAHASHI Hiroaki  Niigata University School of Medicine, University Hospital, 医学部附属病院, 助手 (90179515)

Co-Investigator(Kenkyū-buntansha) TAKEUCHI Shoshichi  Niigata University School of Medicine,Proffesor, 医学部, 教授 (30009914)
YOSHIYA Norio  Niigata University School of Medicine,Assistant, 医学部, 助手 (90183706)
KANAZAWA Koji  Niigata University School of Medicine, Associate Professor, 医学部, 助教授 (50092680)
Project Period (FY) 1986 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1987: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1986: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywordschoriocarcinoma / pulmonary metastasis / class II HLA / Metastatic factor / 形質転換 / class【II】HLA
Research Abstract

Metastatic choriocarcinomas to the brain are often lethal to the patients and they are well known to come from pulmonary metastatic lesions. DNAs from metastatic GCH-1(m) cells were transfered into non-metastatic GCH-1 cells and then these transformants were inoculated subcutaneously into nude mice. Eight weeks later, metastatic tumors were yielded in lungs of all mice. LT-cell line was established from the lung tumors after injection of the transformants. GCH-1(m) DNAs were transfected into another human gestational choriocarcinoma cell line and a human ovarian carcinoma cell line. The transformants of these cell lines inoculated into nude mice, yielded lung tumors in the mice only after inoculation of transfected choriocarcinoma cells. Northern Analysis showed that GCH-1, GCH-1(m) and LT-1 transcribed class I MHC mRNA, but only GCH-1 cells transcribed class II MHC - and -chain mRNA. On the contrary, GCH-1(m) and LT-1 transcribed just H-ras mRNA without transcription of class II MHC mRNA.

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] 安達茂実: 日産婦誌. 38. 961-962 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Hiroaki,TAKAHASHI: Plecete. 8. 293-298 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 安達茂実: 1塩底. 41. 882-883 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 安達茂実: 日産婦誌. 39. 641-648 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Hiroaki,TAKAHASHI: Aan.J.Obsted & Gyaec.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Hiroaki,TAKAHASHI: Plecents.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Shigemi,Adachi: "Establishment and Characterization of a Pulmonary Metastatic Cell Line Derived from Human Choriocarcinoma Cell Line(GCH-1)" Acta Obstet. Gynec. Japonica. 38. 961-962 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Hiroaki,TAKAHASHI: "Epression of HLA-DR molecules in human gestational choriocarcinoma cell lines and other malignant cell lines" Placenta. 8. 293-298 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Shigemi,Adachi: "Establishment and characterization of a cell line(GCH-1) highly metastasizing to lung in nude mice" Acta Obstet. Gynec. Japonica. 39. 641-648 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Hiroaki,TAKAHASHI: "A non-metastatic choriocarcinoma was changed to metastatic by transfer of metastatic choriocarcinoma DNA" Am.J.Obstet. Gynec.submitted.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Hiroaki,TAKAHASI: "Differential transcription of HLA-DR,-DQ and -DP in human gestational choriocarcinoma cells" Placenta. submitted.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Hiroaki Takahashi: Placenta. 8. (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] Hiroaki TAKAHASHI: Cancer Res.

    • Related Report
      1986 Annual Research Report
  • [Publications] Hiroaki takahashi: Camur Res.

    • Related Report
      1986 Annual Research Report
  • [Publications] Koji Kanazawa: Am.J.Obstet.& Gynec.

    • Related Report
      1986 Annual Research Report
  • [Publications] 安達茂実: 日本産科婦人科学会雑誌. 38. 961-962 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 安達茂実: 日本産科婦人科学会雑誌. 39. (1987)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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