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A serological study of tumour specific membrane antigens of cultured ovarian cancer cell lines

Research Project

Project/Area Number 61570797
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionKagawa Medical School

Principal Investigator

HIGUCHI Masaomi  Assistant Professor Perinato-Gynecology, Kagawa Medical School, 医学部附属病院, 講師 (70089837)

Co-Investigator(Kenkyū-buntansha) HANDO Tamotu  Professor Perinato-Gynecology, Kagawa Medical School, 医学部, 教授 (40092720)
TANAKA Kohei  Assistant Professor Perinato-Gynecology, Kagawa Medical School, 医学部附属病院, 講師 (10171753)
KODAMA Syouji  Assistant Professor Perinato-Gynecology, Kagawa Medical School, 医学部附属病院, 講師 (30153563)
TAKEUCHI Yutaka  Assistant Perinato-Gynecology, Kagawa Medical School, 医学部, 助手 (50171624)
Project Period (FY) 1986 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1987: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1986: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsCancer specific antigen / Alloantigen / OFA-I / OFA-I / IA反応
Research Abstract

Humoral antibodies to tumour associated antigens of cultured human ovarian cancer cell lines were studied using the immune adherence (IA) test. One hendred seventy three sera from 12 ovarian cancer patients were tested ageinst two ovarian cancer cell lines ; Kubo and L-Kubo. Sera from 2 patients were IA positive to L-Kubo cell line and sera from 4 patientes to Kubo cell line after absorption with bovine erythrocytes to exclude antibody to heterologous membrane antigens and after further absorption with lymphoblastoid cells autologous to these cell lines.
Aftr absorption with OFA rich tissue (fetal brain), no reactivity remained in the sera samples. These results indicate the sera of patients with breast cancer contain antibodies to OFA-I,but do not detect ovarian histologic type specific antigens as tested by IA using two ovarian cancer cultured cell lines.

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] 樋口正臣,竹内裕,児玉省二,半藤保: 日産婦中・四国合同地方部会雑誌. 34(2). 112-116 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 樋口正臣,竹内裕,半藤保: 日産婦中・四国合同地方部会雑誌. 34(2). 131-134 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] M,Higuchi;M,Takahashi;Y,Takeuchi;T,Hando;S,Takeuchi: Asia-Oceania J.obstet.Gynecol.12(3). 419-423 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 樋口正臣,竹内裕,竹内正七: 産科と婦人科. 53(11). 1651-1657 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 樋口正臣: 日産婦誌. 39(8). 1221-1229 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 樋口正臣: 臨床婦人科産科. 42(1). 41-45 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 樋口正臣: "産婦人科 Mook「癌胎児蛋白」" 金原出版, 81-87 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] M.Higuchi et al.: "Clinical significance of Oncofetal antigen-I in the stem cell assay" The Chugoku & Sikoku Districts Journal the Japan Society of Obstetrics and Gynecology. 34(2). 112-116 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] M.Higuchi et al.: "Prognosis of ovarian cancer patient and levels of antibody to oncofetal antigen-I" The chugoku & Sikoku Districts Journal the Japan Sciet of Obstetrics and Gynecology. 34(2). 131-134 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] M.Higuchi et al.: "The clinical signifiance of antibody against oncofetal antigen-I (anti-OFA-I) in patients with gynecologic tumors" Asia-Oceania J. Obstet. Gynecol.12(3). 419-423 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] M.Higuchi et al.: "Basic and clinical significance of Oncofetal antigen-I" San to Fu (JAP). 53(11). 1651-1657 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] M.Higuchi: "Basic and clinical significance of immunogenic oncofetal antigen (OFA-I)" Acta Obstertrica et Gynaecologica Japonica. 39(8). 1221-1229 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] M.Higuchi: Oncofetal antigens. Sanfujinka Mook, Kanehara-Shuppan(Jap),Tokyo, 81-87 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 樋口正臣: 臨床婦人科産科. 40(7). 520-523 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 樋口正臣,竹内裕,児玉省二,半藤保: 日本産科婦人科学会中国四国合同地方部会雑誌. 34(2). 112-116 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 樋口正臣,竹内裕,半藤保: 日本産科婦人科学会中国四国合同地方部会雑誌. 34(2). 131-134 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 樋口正臣,竹内裕,竹内正七: 産科と婦人科. 53(11). 1651-1657 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 樋口正臣,竹内裕,竹内正七: 日本産科婦人科学会雑誌. 38(11). 1964-1968 (1986)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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