A serological study of tumour specific membrane antigens of cultured ovarian cancer cell lines
| Project/Area Number |
61570797
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kagawa Medical School |
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Principal Investigator |
HIGUCHI Masaomi Assistant Professor Perinato-Gynecology, Kagawa Medical School, 医学部附属病院, 講師 (70089837)
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| Co-Investigator(Kenkyū-buntansha) |
HANDO Tamotu Professor Perinato-Gynecology, Kagawa Medical School, 医学部, 教授 (40092720)
TANAKA Kohei Assistant Professor Perinato-Gynecology, Kagawa Medical School, 医学部附属病院, 講師 (10171753)
KODAMA Syouji Assistant Professor Perinato-Gynecology, Kagawa Medical School, 医学部附属病院, 講師 (30153563)
TAKEUCHI Yutaka Assistant Perinato-Gynecology, Kagawa Medical School, 医学部, 助手 (50171624)
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| Project Period (FY) |
1986 – 1987
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| Project Status |
Completed (Fiscal Year 1987)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1987: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1986: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | Cancer specific antigen / Alloantigen / OFA-I / OFA-I / IA反応 |
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| Research Abstract |
Humoral antibodies to tumour associated antigens of cultured human ovarian cancer cell lines were studied using the immune adherence (IA) test. One hendred seventy three sera from 12 ovarian cancer patients were tested ageinst two ovarian cancer cell lines ; Kubo and L-Kubo. Sera from 2 patients were IA positive to L-Kubo cell line and sera from 4 patientes to Kubo cell line after absorption with bovine erythrocytes to exclude antibody to heterologous membrane antigens and after further absorption with lymphoblastoid cells autologous to these cell lines.
Aftr absorption with OFA rich tissue (fetal brain), no reactivity remained in the sera samples. These results indicate the sera of patients with breast cancer contain antibodies to OFA-I,but do not detect ovarian histologic type specific antigens as tested by IA using two ovarian cancer cultured cell lines.
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Report
(2 results)
Research Products
(18 results)
