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Investigation of the Inner Ear Fluids by Means of Measurements of Blood Flow, Oxygen Tension and Hydrostatic Pressure

Research Project

Project/Area Number 61570825
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionKochi Medical School

Principal Investigator

KISHIMOTO Seiji  Kochi Medical School, Assistant Professor, 医学部, 講師 (30115828)

Co-Investigator(Kenkyū-buntansha) TAKEUCHI Shunji  Kochi Medical School, Assistant, 医学部, 助手 (50188158)
KIMURA Tadashi  Kochi Medical School, Assistant, 医学部, 助手 (70177921)
田島 和幸  高知医科大学, 医学部, 助手 (10163453)
Project Period (FY) 1986 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1987: ¥100,000 (Direct Cost: ¥100,000)
Fiscal Year 1986: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsInner ear fluids / Hydrogen clearance / Hydrostatic pressure / Oxygen tension / 浸透圧利尿剤 / 内耳血流量 / 内耳液圧
Research Abstract

1. Hydrogen clearance (HC) of the endolymph and perilymph in guinea pigs was simultaneously measured and T1/2 of HC was calculated as an index of the metabolism of the inner ear fluids. The results are as follows: 1)T1/2 of HC of the endolymph was significantly shorter than that of the perilymph. 2) Furosemide induced no significant change of T1/2 HC of neither the endolymph nor the perilymph. 3) Glycerol significantly shortened T1/2 of HC in both of the endolymph and perilymph.
2. Hydrostatic pressures of the endolymph and perilymph in guinea pigs were measured simultaneously using servo-nulling pressure measuring system. On physiological condition, there was no difference between the hydrostatic pressures of the endolymph and erilymph. During anoxia and after the administration of glycerol, there was no difference between the two pressures, also.

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] 木村正,竹田泰三,岸本誠司,鎮西邦彦,齋藤春雄: Audiology Japan. 30. 605-606 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 竹田泰三,竹田俊二,鎮西邦彦,齋藤春雄: Equilibrium Research. Suppl.2. 26-30 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 木村正,竹田泰三,岸本誠司,鎮西邦彦,齋藤春雄: Ear Research Japan. 19. (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 木村正,竹内泰三,岸本誠司,鎮西邦彦,齋藤春雄: Equilibrium Research. 47. (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 竹内俊二,竹田泰三,岸本誠司,齋藤春雄: Equilibrium Research. 47. (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] T. Kimura, T. Takeda, S. Kishimoto, K. Chinzei and H. Saito: "Measurements of Hydrogen Clearance of the Endolymph and Perilymph" Audiology Japan. 30. 605-606 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] T. Takeda, S. Takeuchi, K. Chinzei and H. Saito: "Simultaneous Measurements of the Hydrostatic Pressure of the Endolymph and Perilymph" Equilibrium Research. Suppl. 2. 26-30 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] T. Kimura, T. Takeda, S. Kishimoto, K. Chinzei and H.Saito: "Simultaneous Measurements of the Hydrogen Clearance of the Endolymph and Perilymph" Ear Research Japan. 19. (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] T. Kimura, T. Takeda, S. Kishimoto, K. Chinzei and H. Saito: "The Hydrogen Clearance of the Endolymph and Perilymph" Equilibrium Research. 47. (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] S. Takeuchi, T. Takeda, S. Kishimoto and H. Saito: "The Hydrostatic Pressures of the Endolymph and Perilymph" Equilibrium Research. 47. (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary

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Published: 1987-03-31   Modified: 2016-04-21  

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