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Study on rat hypothalamus arcuate nucleus which plays an important role in the induction of acupuncture analgesia.

Research Project

Project/Area Number 61570893
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Functional basic dentistry
Research InstitutionShowa University

Principal Investigator

HAMBA Michiko  Department of Physiology, School of Dentistry, 歯学部, 講師 (40119251)

Project Period (FY) 1986 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1987: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1986: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywordsarcuate nucleus / electroacupuncture analgesia / Opioids / 針刺激
Research Abstract

To evaluate the possible role of the arcuate nucleus of hypothalamus (ARH) in the antinociceptive system, the following experiments were carried out, using male Wistar rats. 1) The effect of ARH lesion on pain control and electroacupuncture (EA) analgesia. The ARH-lesioned rats showed a significantly high value in pain rating of the formalin test 30 days after, indicating that they were hypersensitive to nociceptive stimuli. An analgesic effect was induced in the control rats by EA stimulation (3 Hz, 300-600 <micr>A) applied at Ho-Ku, but scarcely seen in the lesioned rats. 2) EA effect on the neuronal activity of ARH. The majority of ARH neurons significantly changed their spontaneous frequency rates (the rate increased or decreased) by EA stimulation. The activity change lasted for about 60 min and its time course agreed with that of the analgesic effect of EA. It suggested that the majority of ARH neurons took part in the analgesia. 3) Relationship between tha analgesic effect of the EA and the possible involvement of endogenous opioids. The analgesic effects and the neuronsl change in ARH induced by EA stimulation were both antagonized by injected naloxone (1mg/Kg, i.p.).<bat>-endorphin in the medialbasal hypothalamus was significantly higher in the animal group immediately killed after reciving EA stimulation for 15 min than in the control animal group. 4) The effect of ARH stimulation on the neuronal activity of the lateral hypothalamic area (LHA). ARH stimulation (20-45 <micr>A, 1-3 Hz, 30 s) induced the suppressive effect on the spontaneous activity of the neurons in the LHA and on the response of the LHA neurons to noxious stimuli. ARH resion thus appears to be an important part in the central pain control system and in the induction of EA analgesia.

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] Hamba,M.and Toda,K.: Experimental Neurology. 87. 118-128 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 半場道子,戸田一雄: 昭和歯学会雑誌. 7. 266 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 半場道子: 昭和歯学会雑誌. 8. (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 半場道子: 日本生理学雑誌. 50. (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Michiko Hamaba and Kazuo Toda: "Acupuncture effects on the neuronal activity of the arcuate nucleus of rat hypothalamus." Experimental Neurology. 87. 118-128 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Michiko Hamba and Kazuo Toda: "Acupuncture effects on the neuronal activity of the arcuate nucleus and the involvement of endogeneous opioids compounds." J. Showa Univ. Dent. Society. 7. 266 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Michiko Hamba: "The effects of the arcuate uncleus lesion on pain control and on electroacupuncture analgeia." J. Showa Univ. Dent. Soci.8. (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Michiko Hamba: "The effect of the arcuate nucleus (ARH) lesion on pain control and on electroacupuncture analgesia, and the effect of ARH stimulation on the neuronal activity of the lateral hypothalamic area." J. Physiol. Soci. Japan.50. (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Hamba,M;Toda,K.: Neurosci.Lett.17s. 138 (1984)

    • Related Report
      1986 Annual Research Report
  • [Publications] Hamba,M;Toda,K.: J.Physiol.Soc.Japan. 46. 456 (1984)

    • Related Report
      1986 Annual Research Report
  • [Publications] Hamba,M;Toda,K: Experimental Neurology. 87. 118-128 (1985)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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