| Project/Area Number |
61570986
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Faculty of Phamaceutical Sciences, Hokkaido University |
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Principal Investigator |
YOSHIDA Kiyoshi (1987) Faculty of Pharmaceutical Sciences, Hokkaido University, 薬学部, 助手 (60109478)
若松 武 (1986) 北海道大学, 薬学部, 助教授 (40001044)
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| Co-Investigator(Kenkyū-buntansha) |
MORI Miwako Faculty of Pharmaceutical Sciences, Hokkaido University, 薬学部, 助教授 (80001981)
WAKAMATSU Takeshi Tsumura Laboratory, 津村研究所, 部長代理 (40001044)
吉田 清史 北海道大学, 薬学部, 助手 (60109478)
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| Project Period (FY) |
1986 – 1987
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| Project Status |
Completed (Fiscal Year 1987)
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| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1987: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1986: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | Antilukemic Sesquiterpene / Eriolanin / Eriolagin / ケテン付加反応 / 抗腫瘍活性セスキテルペン / αメチレンδラクトン |
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| Research Abstract |
Eriolanin(1) and eriolanin(2) are novel antileukemic 1,10-seco-eudesmanokides which were isolated from Eriophyllum lanatum Forbes (Compositae) by Kupchan and corworkers during a search for tumor-inhibitory natural products from plant sources. Both eriolanin and eriolangin were found to be possess significant in vivo activity against P388 leukemia in mice and in vitro activity against cell cultures derived from human carcinoma of the nasophargyx (KB).
The total synthesis of these natural products has been achived by our investigators in this research project for a term of two years.
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