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Chemical Studies on Crude Drug Processing

Research Project

Project/Area Number 61571001
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Chemical pharmacy
Research InstitutionOsaka University

Principal Investigator

YOSHIKAWA Masayuki  Osaka University (Assistant Professor), 薬学部, 助教授 (90116129)

Co-Investigator(Kenkyū-buntansha) SHIBUYA Hirotaka  Osaka University (Assistant), 薬学部, 助手 (50116042)
Project Period (FY) 1986 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1987: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1986: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsCrude drug processing / Chinese traditional medicine / Rehmanniae Radix / Licorice Root / rehmaglutins / glutinoside / rehmaionosides / rehmapicroside / トリテルペンオリゴ配糖体 / 熟地黄
Research Abstract

Crude drug processing was known to be an important segment of Chinese traditional medicine. As a part of our chemical characterization studies on crude drug processing, we have been working on Rehmanniae Radix and Licorice Root. Rehmanniae Radix is classified into three types named in Japanese as sho-jio (fresh root), kan-jio (dried root), and juku-jio (steamed root), which are used in different manners in Chinese traditional madicine. We have compared the chemical constituents of differently processed Chinese, Korean and Japanese Rehmanniae Radix and have so far elucidated four new iridoids (rehmaglutins A, B, C and D), a new chlorinated iridoid glucoside (glutinoside), three new inone glucosides (rehmaionosides A, B and C), and a new monoterpene glucoside (rehmapicroside), which were isolated from Chinese Rehmanniae Radix (kan-jio, identified as Rehmannia glutinosa, and juku-jio). We have also found that rehmaionosides A and B relax the normal tone in mouse bladder strips and inhibit the noradrenaline induced contraction in the urethral strips.
Licorice Root is one of the best known Chinese crude drugs and often used in many Chinese medicinal preparation after various procession. We have isolated eight new triterpene oligoglycosides (licorice-saponins A3, B2, C2, D3, E2, F3, G2, H2) from Chinese Licorice Root and have elucidated their chemical structures.

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] Isao Kitagawa: Chem.Pharm.Bull.34. 1399-1402 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Masayuki Yoshikawa: Chem.Pharm.Bull.34. 1430-1406 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Masayuki Yoshikawa: Chem.Pharm.Bull.34. 2294-2297 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 北川勲: 現代東洋医学. 17. 55-62 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 北川勲: からだの科学臨時増刊新版東洋の医学. 136-144 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 北川勲: 薬学雑誌. 107. 495-505 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Isao Kitagawa: "Absolute Stereostructures of Rehmaglutins A, B, and D Three New Iridoids Isolated from Chinese Rehmanniae Radix" Chem. Pharm. Bull.34. 1399-1402 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Masayuki Yoshikawa: "Absolute Stereostructures of Rehmaglutin C and Glutinoside. A New Iridoid Lactone and a New Chlorinated Iridoid Glucoside from Chinese Rehmanniae Radix" Chem. Pharm. Bull.34. 1403-1406 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Masayuki Yoshikawa: "Absolute Configurations of Rehmaionosides A, B, and C and Rehmapicroside. Three New Ionone Glucosides and a New Monoterpene Glucoside from Rehmanniae Radix" Chem. Pharm. Bull.34. 2294-2297 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Isao Kitagawa: "Chemical Constituents of Rehmanniae Radix Corne Fructus, and Discorea Rhizoma" Gendai Toyo Igaku. 17. 55-62 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Isao Kitagawa: "Chemistry of Oriental Crude Drug" Popular Medicine, Toyo no Igaku. 136-144 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Isao Kitagawa: Chem.Pharm.Bull.34. 1399-1402 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Masayuki Yoshikawa: Chem.Pharm.Bull.34. 1403-1406 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Masayuki Yoshikawa: Chem.Pharm.Bull.34. 2294-2297 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 北川勲: 現代東洋医学. 17. 55-62 (1986)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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